Measuring Vitamin D Levels in Fat Tissues of Obese and Non-obese Patients
Vitamin D and Its Metabolites Quantification in Adipose Tissues of Obese and Non-obese
This study looks at Vitamin D levels in fat from both obese and non-obese patients to see how obesity affects Vitamin D in the body.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Assistance Publique Hopitaux De Marseille Academic / other |
| Locations | 1 site (Marseille) |
| Trial ID | NCT03008525 on ClinicalTrials.gov |
What this trial studies
This study aims to investigate the levels of Vitamin D and its metabolites in the adipose tissues of both obese and non-obese patients. By conducting biopsies of subcutaneous and visceral fat, along with blood sample analyses, the researchers seek to confirm whether Vitamin D is sequestered or diluted in adipose tissue, which may explain the lower circulating levels of Vitamin D observed in obese individuals. The study focuses on patients undergoing bariatric or abdominal surgery, allowing for a direct comparison between the two groups. The findings could provide insights into the relationship between obesity and Vitamin D metabolism.
Who should consider this trial
Good fit: Ideal candidates include individuals with a BMI greater than 35 kg/m² for the obese group or less than 30 kg/m² for the non-obese group, who are undergoing bariatric or abdominal surgery.
Not a fit: Patients who regularly take dietary or vitamin supplements, or those who are malnourished or have infections, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of Vitamin D metabolism in obesity, potentially leading to improved treatment strategies for obesity-related health issues.
How similar studies have performed: While there is existing literature on the relationship between obesity and Vitamin D levels, this specific approach of quantifying Vitamin D in adipose tissues is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subject with a BMI greater than 35 kg / m2 (group OB) or less than 30 kg / m² (group NO) * Subject undergoing bariatric surgery (OB group) or abdominal surgery (group NO) Exclusion Criteria: * Regular intake of dietary supplements or vitamin supplements in the last three months * For the subjects of the group NO: * Malnourished patient (BMI \<18.5 kg / m2, weight loss greater than 5% in 1 month or 10% in 6 months) * Subject with an infection or inflammatory syndrome (CRP\> 10 mg / L and / or white blood cells\> 12000 / mm3) * Non-cancerous subject
Where this trial is running
Marseille
- Assistance Publique Hôpitaux de Marseille — Marseille, France (Recruiting)
Study contacts
- Study coordinator: Rene VALERO
- Email: rene.valero@ap-hm.fr
- Phone: 0491383393
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.