Measuring urine S1P to detect overactive bladder in people with multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will measure urinary S1P levels in French patients with multiple sclerosis who are scheduled for urodynamic evaluation at Toulouse University Hospital. Urine samples will be collected and analyzed for S1P and compared with simultaneous urodynamic measurements of detrusor activity. Patients with active urinary tract infection, pregnancy, legal guardianship restrictions, or specific pelvic/bladder conditions are excluded. The aim is to confirm whether urinary S1P correlates with invasive urodynamic findings and could serve as a noninvasive biomarker.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* French residents enrolled in the social security system
* Patients diagnosed with multiple sclerosis (according to McDonald 2017 criteria), whether receiving treatment or not
* Patients scheduled for urodynamic assessment as part of their management

Exclusion criteria:

* Pregnant or lactating females
* Patients under legal guardianship
* Untreated urinary tract infection at the time of inclusion
* Known anatomical subvesical obstruction Known pelvic floor disorder Urothelial carcinoma Interstitial cystitis Augmentation cystoplasty

Where it's running

• Toulouse Hospital
  Toulouse, France Recruiting

Study contacts

• Principal investigator: Xavier Game, MD — University Hospital, Toulouse
• Study coordinator: Xavier Game, MD
• Email: game.x@chu-toulouse.fr
• Phone: 05 61 32 33 01

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.