Measuring treatment response in malignant pleural mesothelioma using breathprinting technology
Official title: Breathprinting (E-Nose) Technology to Measure Response to Treatment of Malignant Pleural Mesothelioma (MPM) Through MPM-Specific Volatile Organic Compounds Detected in Exhalates
Run by Memorial Sloan Kettering Cancer Center · NCT06037941 · Data updated 2026-11-12
This study is testing if a special breath-sensing device can help track how well treatment is working for people with malignant pleural mesothelioma.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 30 Years to 85 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Memorial Sloan Kettering Cancer Center Academic / other |
| Locations | 7 sites (Basking Ridge, New Jersey and 6 other locations) |
| Status | Recruiting |
| Started | September 8, 2023 |
| Main results expected | September 2027 |
| Study ends | September 2027 |
| Registry record updated | September 24, 2026 |
| Trial ID | NCT06037941 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 30-85 who have recently been diagnosed with malignant pleural mesothelioma and have no history of thoracic or extrathoracic cancers.
✕Probably not a fit
Patients under 30 or over 85 years old, or those with a history of thoracic or extrathoracic cancer that could lead to pleural metastases, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the use of electronic nose (E-Nose) technology to assess how patients with malignant pleural mesothelioma respond to standard treatment. Researchers will analyze changes in breathprints over time and compare these changes to standard imaging scans and blood biomarkers. The goal is to determine if E-Nose can provide a non-invasive method to monitor treatment efficacy in these patients.
Why it matters
Potential benefit: If successful, this approach could offer a new, non-invasive way to monitor treatment responses in patients with malignant pleural mesothelioma.
How similar studies have gone: While the use of breathprinting technology is relatively novel, similar studies have shown promise in other conditions, suggesting potential for success in this application.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 30-85 years * No history of thoracic cancer or extrathoracic cancer potentially involving pleural metastases (i.e., breast, gastric, colon, or pancreas cancer) * Recent diagnosis of MPM * Documented, signed, and dated informed consent, obtained before any procedures, for the proposed research study, and signed standard surgical consent for surgical resection Exclusion Criteria: * Aged \<30 or \>85 years at the first outpatient visit * History of thoracic or extrathoracic cancer that puts the subject at risk for pleural or pulmonary metastases
Where it's running
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Memorial Sloan Kettering Basking Ridge (Consent Only)
Basking Ridge, New Jersey, United States Recruiting -
Memorial Sloan Kettering Monmouth (Consent Only)
Middletown, New Jersey, United States Recruiting -
Memorial Sloan Kettering Bergen (Consent Only )
Montvale, New Jersey, United States Recruiting -
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Consent Only)
Commack, New York, United States Recruiting -
Memorial Sloan Kettering Westchester (Consent Only)
Harrison, New York, United States Recruiting -
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States Recruiting
Show 1 more location
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Memorial Sloan Kettering Nassau (Consent Only)
Uniondale, New York, United States Recruiting
Study contacts
- Principal investigator: Gaetano Rocco, MD — Memorial Sloan Kettering Cancer Center
- Study coordinator: Gaetano Rocco, MD
- Email: roccog@mskcc.org
- Phone: 212-639-3478
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Combining a PD-L1 inhibitor and dendritic cell vaccination with chemotherapy for malignant pleural mesothelioma
This study is testing a new treatment that combines a PD-L1 blocker and a special vaccine with chemotherapy to see if it helps people with a type of lung cancer called malignant pleural mesothelioma.
-
Proton therapy for treating malignant pleural mesothelioma
This study is testing if proton therapy can help people with malignant pleural mesothelioma live longer and feel better compared to standard care.
-
Innovative treatment combining photodynamic therapy and immunotherapy for malignant pleural mesothelioma
This study is testing a new treatment that combines light therapy and immune therapy to see if it can help patients with advanced malignant pleural mesothelioma who haven't responded well to chemotherapy.
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APG-2449 for advanced solid tumors
This study is testing a new oral medication called APG-2449 to see how well it works and what the safe dosage is for people with advanced solid tumors like non-small cell lung cancer.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.