Clinical trial Recruiting at 7 sites Interventional Ages 30 to 85

Measuring treatment response in malignant pleural mesothelioma using breathprinting technology

Official title: Breathprinting (E-Nose) Technology to Measure Response to Treatment of Malignant Pleural Mesothelioma (MPM) Through MPM-Specific Volatile Organic Compounds Detected in Exhalates

Run by Memorial Sloan Kettering Cancer Center · NCT06037941 · Data updated 2026-11-12

This study is testing if a special breath-sensing device can help track how well treatment is working for people with malignant pleural mesothelioma.

Quick facts

Study typeInterventional
Ages30 Years to 85 Years
SexAll
Enrollment20 (estimated)
SponsorMemorial Sloan Kettering Cancer Center
Academic / other
Locations7 sites (Basking Ridge, New Jersey and 6 other locations)
StatusRecruiting
StartedSeptember 8, 2023
Main results expectedSeptember 2027
Study endsSeptember 2027
Registry record updatedSeptember 24, 2026
Trial IDNCT06037941 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 30-85 who have recently been diagnosed with malignant pleural mesothelioma and have no history of thoracic or extrathoracic cancers.

Probably not a fit

Patients under 30 or over 85 years old, or those with a history of thoracic or extrathoracic cancer that could lead to pleural metastases, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of electronic nose (E-Nose) technology to assess how patients with malignant pleural mesothelioma respond to standard treatment. Researchers will analyze changes in breathprints over time and compare these changes to standard imaging scans and blood biomarkers. The goal is to determine if E-Nose can provide a non-invasive method to monitor treatment efficacy in these patients.

Why it matters

Potential benefit: If successful, this approach could offer a new, non-invasive way to monitor treatment responses in patients with malignant pleural mesothelioma.

How similar studies have gone: While the use of breathprinting technology is relatively novel, similar studies have shown promise in other conditions, suggesting potential for success in this application.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Aged 30-85 years
* No history of thoracic cancer or extrathoracic cancer potentially involving pleural metastases (i.e., breast, gastric, colon, or pancreas cancer)
* Recent diagnosis of MPM
* Documented, signed, and dated informed consent, obtained before any procedures, for the proposed research study, and signed standard surgical consent for surgical resection

Exclusion Criteria:

* Aged \<30 or \>85 years at the first outpatient visit
* History of thoracic or extrathoracic cancer that puts the subject at risk for pleural or pulmonary metastases

Where it's running

  • Memorial Sloan Kettering Basking Ridge (Consent Only)
    Basking Ridge, New Jersey, United States
    Recruiting
  • Memorial Sloan Kettering Monmouth (Consent Only)
    Middletown, New Jersey, United States
    Recruiting
  • Memorial Sloan Kettering Bergen (Consent Only )
    Montvale, New Jersey, United States
    Recruiting
  • Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Consent Only)
    Commack, New York, United States
    Recruiting
  • Memorial Sloan Kettering Westchester (Consent Only)
    Harrison, New York, United States
    Recruiting
  • Memorial Sloan Kettering Cancer Center (All Protocol Activities)
    New York, New York, United States
    Recruiting
Show 1 more location
  • Memorial Sloan Kettering Nassau (Consent Only)
    Uniondale, New York, United States
    Recruiting

Study contacts

  • Principal investigator: Gaetano Rocco, MD — Memorial Sloan Kettering Cancer Center
  • Study coordinator: Gaetano Rocco, MD
  • Email: roccog@mskcc.org
  • Phone: 212-639-3478

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.