Measuring thigh muscle in critically ill children using ultrasound and MRI
Comparison of Quadriceps Femoris Measurements in Critically Ill Children, Using Bedside Ultrasound and Magnetic Resonance Imaging
This study is testing if ultrasound can accurately measure thigh muscle in critically ill children, compared to MRI, to help doctors better monitor their muscle health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 35 (estimated) |
| Ages | 1 Year to 17 Years |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Bron) |
| Trial ID | NCT05108441 on ClinicalTrials.gov |
What this trial studies
This study aims to validate the use of ultrasound measurements of the quadriceps femoris muscle as a surrogate for assessing muscle mass in critically ill children. It involves comparing ultrasound measurements with magnetic resonance imaging (MRI) to ensure accuracy and reproducibility. The study focuses on children aged 0 to 17 years who are critically ill and require MRI for medical reasons. By establishing the reliability of ultrasound, the study seeks to improve monitoring of muscle mass in pediatric intensive care settings.
Who should consider this trial
Good fit: Ideal candidates for this study are critically ill children aged 0 to 17 years who are sedated and have a planned MRI for medical reasons.
Not a fit: Patients with congenital neuromuscular diseases or those who cannot safely undergo ultrasound or MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the ability to monitor and manage muscle mass loss in critically ill children, potentially improving their recovery outcomes.
How similar studies have performed: While similar studies have explored ultrasound for muscle mass assessment, this specific validation against MRI is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * critically ill children from 0 to 17 years old * magnetic resonance imaging planned for any medical reason * sedated child for any medical reason * absence of parental/patient refusal to participate to the study Exclusion Criteria: * congenital neuromuscular disease * no possible access to the thigh (e.g. dressing, drains, gypsum) * anatomical anomaly of the limb, that would compromise localizing thigh landmarks (patella, groin) * inability to obtain limb rest and/or thigh muscle decontraction * risk induced by mobilization of the patient for ultrasound or magnetic resonance imaging purpose * absence of social insurance
Where this trial is running
Bron
- Paediatric intensive care - Hospices Civils de Lyon — Bron, France (Recruiting)
Study contacts
- Principal investigator: VALLA Frédéric, Pr — Hospices Civils de Lyon
- Study coordinator: VALLA Frédéric, Pr
- Email: Frederic.valla@chu-lyon.fr
- Phone: +33 472 12 97 44
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.