Measuring the effects of Tranexamic Acid during heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the antifibrinolytic activity of Tranexamic Acid (TXA) during cardiac surgery using a new point-of-care diagnostic assay. The trial aims to determine the optimal dosing of TXA to minimize postoperative blood loss and reduce the need for blood transfusions. Patients undergoing elective cardiac procedures such as aortocoronary artery bypass graft surgery or valve replacements will receive varying doses of TXA, allowing for real-time adjustments based on the assay results. The study seeks to establish a standardized approach to TXA administration in the operating room.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Eligible patients:

* Over 18 years old
* Elective surgery
* Written informed consent
* Patient planned for aortocoronary artery bypass graft surgery, aortic valve replacement or mitral valve surgery (or a combination of these procedures)
* Normal renal function
* No previous intake of anticoagulants except acetylsalicylic acid in the preoperative period

Exclusion Criteria:

* Impaired renal function (eGFR \< 30 ml/min.)
* History of seizure
* Pregnancy
* Inability to understand and sign the informed consent (e.g., language problems, dementia, psychological disorders)

Where it's running

• Dpt. Anesthesiology and pain Medicine
  Bern, Switzerland Recruiting

Study contacts

• Principal investigator: Annegret Kauert-Willms, MD — University Hospital Berne
• Study coordinator: Gabor Erdoes, MD
• Email: Gabor.erdoes@insel.ch
• Phone: ++41 31 632 2726

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.