Measuring retinal blood vessel density in patients with microvascular angina

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of Optical Coherence Tomography-Angiography (OCT-A) to measure retinal vascular density in patients diagnosed with microvascular angina, a condition characterized by impaired blood flow in the heart's microcirculation. The study aims to provide a non-invasive and cost-effective alternative to the invasive measurement of microcirculatory resistance index (MRI) for diagnosing this condition. By correlating retinal microcirculation with cardiac health, the research seeks to enhance diagnostic accuracy and patient management. Participants will undergo blood sampling, ophthalmological examinations, and complete an angina severity questionnaire.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients managed at Dijon University Hospital, having had an IMR measurement as part of INOCA during a coronary angiographic examination, consecutively includible, without angiographically or functionally significant coronary epicardial lesion (FFR \< 0.80) explaining the clinical picture (= INOCA)
* Person having given oral consent
* Adult

Exclusion Criteria:

* Person not affiliated or not benefiting from a social security scheme
* Person subject to a legal protection measure (curatorship, guardianship) or a safeguard of justice measure
* Pregnant or breast-feeding women
* An adult incapable or unable to give consent
* Person with macular or retinal pathology, or severe bilateral myopia
* Person with genetic or idiopathic cardiomyopathy (dilated, hypertrophic or restrictive cardiomyopathy)

Where it's running

• CHU Dijon Bourgogne
  Dijon, France Recruiting

Study contacts

• Study coordinator: Pierre GUILLEMINOT
• Email: pierre.guilleminot@chu-dijon.fr
• Phone: 0380293031

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Polish registry of heart nerve–targeting treatments (cardioneuroablation and cardioneuromodulation)

  This registry collects information to see how nerve-targeting heart procedures work for adults with fainting, abnormal heart rhythms, or orthostatic problems.

  Recruiting SABAMED Medical Center Ltd. · Rzeszów · NCT07196397

• Comprehensive coronary physiology testing for adults with angina but no blocked coronary arteries in the Czech Republic

  This project will test detailed invasive coronary physiology and vasospasm tests in adults who have angina but no major coronary blockages to see if microvascular dysfunction or spasms explain their symptoms.

  Recruiting University Hospital, Motol · Prague, Česká Republika · NCT07103317

• Personalized exercise and dietary program for patients with microvascular coronary dysfunction

  This study is testing a personalized exercise and diet program to see if it helps people with microvascular coronary dysfunction feel better and manage their symptoms.

  Recruiting at 2 sites Royal United Hospitals Bath NHS Foundation Trust · Bath and 1 other locations · NCT06681896

• Targeted medical therapy for angina with non-obstructive coronary arteries

  This study is testing if a new targeted medication can help people with angina and non-obstructive coronary arteries feel better and improve their quality of life.

  Recruiting Phase 2/3 Stanford University · Palo Alto, California · NCT06424834

• Evaluating coronary microvascular dysfunction in heart failure patients

  This study is trying to see if problems with tiny blood vessels in the heart affect how well people with heart failure can improve their heart function after treatment.

  Recruiting Samsung Medical Center · Seoul · NCT06243653

• Treatment for Microvascular Angina with Danshen Pills

  This study is testing if Danshen pills can help people with microvascular angina feel better by improving their chest pain and blood flow.

  Recruiting Phase 4 Qilu Hospital of Shandong University · Jinan, Shandong · NCT06092736

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.