Measuring protein digestibility using a dual-isotope method
Official title: Validation of the Dual-isotope Method for Measuring Ileal Protein Digestibility
Run by Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · NCT05426551 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing a new way to measure how well healthy adults can digest protein from a special egg to see if it works better than traditional methods.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 36 (estimated) |
| Sponsor | Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement Academic / other |
| Locations | 1 site (Bobigny) |
| Trial ID | NCT05426551 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy men and women aged 18 to 45 with a BMI between 18 and 30.
✕Probably not a fit
Patients with any digestive or hepatic pathology, allergies to eggs or latex, or those who are pregnant will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the digestibility of indispensable amino acids (IAAs) from a specially prepared 2H-labeled hen's egg protein in healthy adults. Participants will consume a test meal containing the labeled protein, and the digestibility will be assessed using both indirect (dual isotope method) and direct (ileal digesta sampling) approaches. The study aims to validate the dual isotope method by comparing its results with direct measurements. A total of 18 healthy volunteers aged 18 to 45 will be recruited for this study, which will take place at the Human Nutrition Research Centre of Avicenne Hospital in France.
Why it matters
Potential benefit: If successful, this study could provide a reliable method for assessing protein digestibility, which may improve dietary recommendations and food formulations.
How similar studies have gone: While the dual isotope method has been recently developed, this study aims to validate its effectiveness, making it a novel approach in this context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18\<BMI\<30 * Healthy * Insured under the French social security system * For women: use of birth control * Signed informed consent Exclusion Criteria: * Any dietary allergy * Latex allergy * Positive serology to HIV, hepatite C virus antibody, hepatite B virus surface antigen and core antibodies * Gluten intolerance * Anemia * Use of drugs * High consumption of alcohol * Hypertension, diabetes, digestive disease, hepatic or renal disease, severe cardiac disease * Pregnancy * High sport practicing (\>7h/wk) * Blood donation in the 3 months prior to the study * Participation in a clinical study in the 3 months prior to the study * No signed informed consent
Where it's running
-
Centre de Recherche sur Volontaires (CRV) de l'hôpital Avicenne
Bobigny, France Recruiting
Study contacts
- Study coordinator: Juliane Calvez, PhD
- Email: juliane.calvez@agroparistech.fr
- Phone: +33144088677
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.