Measuring Nimodipine Levels in Patients with Aneurysmal Subarachnoid Hemorrhage
Official title: Determination of Cerebral Nimodipine Concentrations Following Oral, Intra-venous and Intra-arterial Administration - a Descriptive Pharmacokinetic/Pharmacodynamics Study
Run by Medical University of Vienna · NCT04649398 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing how different ways of giving nimodipine affect its levels in the blood and brain of patients with a type of brain bleed, to see how it might help protect their brain and improve their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 95 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Medical University of Vienna Academic / other |
| Locations | 1 site (Vienna) |
| Trial ID | NCT04649398 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 years old who have experienced an aneurysmal subarachnoid hemorrhage and require intensive care with brain microdialysis.
✕Probably not a fit
Patients who have contraindications for nimodipine or do not require intensive care and microdialysis will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to measure the concentrations of nimodipine in the blood, cerebrospinal fluid, and brain tissue following different routes of administration (oral, intravenous, and intra-arterial) in patients with aneurysmal subarachnoid hemorrhage. The study will correlate these concentrations with measures of cerebral metabolism and oxygenation to better understand the drug's neuroprotective effects and potential risks. By investigating the pharmacokinetics of nimodipine, the study seeks to clarify the optimal dosing regimen for improving patient outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved dosing strategies for nimodipine, enhancing patient recovery and reducing the risk of delayed cerebral ischemia.
How similar studies have gone: While the approach of measuring drug concentrations in this context is not widely tested, previous studies have shown the importance of nimodipine in managing subarachnoid hemorrhage, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patient age \> 18 years * aneurysmal subarachnoid hemorrhage * sedated and mechanically ventilated * application of brain microdialysis as standard care (due to the severity of subarachnoid haemorrhage or secondary deterioration) * oral, intra-venous or intra-arterial administration of nimodipine due to clinical indication Exclusion Criteria: * contraindication for nimodipine * no need of intensive care and bedside cerebral microdialysis as standard care * any disease considered relevant for proper performance of the study or risks to the patient, at the discretion of the investigator
Where it's running
-
Medical University of Vienna
Vienna, Austria Recruiting
Study contacts
- Study coordinator: Arthur Hosmann, MD PhD
- Email: arthur.hosmann@meduniwien.ac.at
- Phone: +43/1/40400
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.