Measuring nerve activity in intestinal biopsies from IBS patients and healthy individuals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study involves taking rectal biopsies from individuals diagnosed with Irritable Bowel Syndrome (IBS) and healthy subjects. The biopsies will be used to isolate the submucosal plexus for live nerve recordings, calcium imaging, immunohistochemistry, and mRNA isolation. The primary goal is to advance understanding of the enteric nervous system in IBS by developing a unique method for live imaging of nerve activity in human intestinal biopsies. This innovative approach aims to provide insights that have not been previously reported in other research.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* IBS patients (based on ROME III Criteria)
* Healthy subjects

Exclusion Criteria:

\- All subjects with not IBS related complaints

Where it's running

• University Hospitals Leuven
  Leuven, Vlaams-Brabant, Belgium Recruiting

Study contacts

• Principal investigator: Guy Boeckxstaens, MD — Catholic University Leuven and Universitary Hospitals Leuven
• Study coordinator: Koen Bellens, MSc
• Email: koen.bellens@kuleuven.be
• Phone: 0032-16-341943

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.