Measuring nerve activity in intestinal biopsies from IBS patients and healthy individuals
Measuring Nerve Activity in Small Human Intestinal Biopsies in IBS (Irritable Bowel Syndrome)
This study is testing a new way to look at nerve activity in the intestines of people with Irritable Bowel Syndrome (IBS) and healthy individuals to better understand how their nervous systems work.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 99999999 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | KU Leuven Academic / other |
| Locations | 1 site (Leuven, Vlaams-Brabant) |
| Trial ID | NCT01912313 on ClinicalTrials.gov |
What this trial studies
This study involves taking rectal biopsies from individuals diagnosed with Irritable Bowel Syndrome (IBS) and healthy subjects. The biopsies will be used to isolate the submucosal plexus for live nerve recordings, calcium imaging, immunohistochemistry, and mRNA isolation. The primary goal is to advance understanding of the enteric nervous system in IBS by developing a unique method for live imaging of nerve activity in human intestinal biopsies. This innovative approach aims to provide insights that have not been previously reported in other research.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with IBS according to ROME III criteria and healthy subjects.
Not a fit: Patients with complaints unrelated to IBS will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of IBS and lead to improved diagnostic and therapeutic strategies for patients.
How similar studies have performed: This approach is novel and has not been previously reported by other research groups.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * IBS patients (based on ROME III Criteria) * Healthy subjects Exclusion Criteria: \- All subjects with not IBS related complaints
Where this trial is running
Leuven, Vlaams-Brabant
- University Hospitals Leuven — Leuven, Vlaams-Brabant, Belgium (Recruiting)
Study contacts
- Principal investigator: Guy Boeckxstaens, MD — Catholic University Leuven and Universitary Hospitals Leuven
- Study coordinator: Koen Bellens, MSc
- Email: koen.bellens@kuleuven.be
- Phone: 0032-16-341943
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.