Measuring muscle health in breast and gynecological cancer patients using near infrared spectroscopy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study recruits breast cancer and gynecological cancer patients to assess the impact of chemotherapy on muscle mitochondrial oxidative capacity. Participants will engage in a controlled exercise session on a stationary bicycle while their quadriceps muscle is evaluated non-invasively using near infrared spectroscopy (NIRS). The study aims to measure changes in oxygenation and deoxygenation status of the muscle, which reflects mitochondrial function, after exercise. Testing will occur at the University of South Carolina's Human Performance Laboratory, with each session lasting approximately 30 minutes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients diagnosed with breast cancer or gynecological cancer without distance metastasis
* Able to perform exercise on a stationary cycle ergometer at moderate intensities for a maximum of 15 minutes
* Hemoglobin values greater than 10 at baseline
* ALT and AST values less than 2.5X the upper limit of normal by institutional standards
* Godin-Shepard Leisure time Physical Activity Questionnaire (GLTEQ) score of 14 or greater will be included. A score of less than 14 is considered insufficiency active/sedentary

Exclusion Criteria:

* Metastatic breast or gynecological cancer
* Clinically advanced cardiovascular disease
* Clinically advanced pulmonary disease
* Disease requiring continuous oxygen supplementation
* Greater than 2 centimeters or more of subcutaneous adipose tissue on the anterior thigh
* Inability to walk or stand
* Movement disorders
* Spinal cord injuries
* Autoimmune disorders
* Pregnant or breastfeeding
* Mini-Mental State Examination (MMSE) \<24

Where it's running

• Prisma Health Cancer Institute
  Greenville, South Carolina, United States Recruiting

Study contacts

• Principal investigator: Jennifer L Trilk, PhD — University of South Carolina School of Medicine, Greenville
• Study coordinator: Jennifer L Trilk, PhD
• Email: trilk@greenvillemed.sc.edu
• Phone: 864-455-1410

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.