Measuring muscle characteristics in patients with cerebral palsy
Official title: Exploration of the Length/Tension Relationship in Spastic Muscle in Vivo and Its Relation to the Muscle's Macromolecular Composition. The Results Are Related to Function Before and After Tendon Transfer/Tendon Lengthenings.
Run by Region Stockholm · NCT05518565 · Data updated 2026-11-12
This study is testing a new way to measure muscle characteristics in people with cerebral palsy to see how muscle tightness and stiffness change as they get older, which could help improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 2 Years to 18 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Region Stockholm Government |
| Locations | 3 sites (Stockholm and 2 other locations) |
| Status | Recruiting |
| Started | January 15, 2002 |
| Main results expected | December 15, 2032 |
| Study ends | December 15, 2033 |
| Registry record updated | August 26, 2022 |
| Trial ID | NCT05518565 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with cerebral palsy or acquired brain injury.
✕Probably not a fit
Patients with progressive neurological diseases will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients with cerebral palsy (CP) to investigate muscle characteristics, specifically sarcomere length, using a novel in vivo measurement technique. The study aims to understand how muscle contracture and spasticity affect the limbs of individuals with CP, particularly as they age. By utilizing laser diffraction to analyze muscle biopsies, researchers hope to gain insights into the optimal surgical interventions needed to improve muscle function and joint positioning. The findings could inform better treatment strategies for managing muscle shortening and related complications in CP.
Why it matters
Potential benefit: If successful, this study could lead to improved surgical techniques and treatment plans for patients with cerebral palsy, enhancing their mobility and quality of life.
How similar studies have gone: While the approach of measuring sarcomere length in vivo is innovative, similar studies have shown promise in understanding muscle dynamics in other conditions, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Celebral Palsy or Aquired Brain Injury Exclusion Criteria: * Progressive neurological disease
Where it's running
-
Karolinska University Hospital
Stockholm, Sweden Recruiting -
Karolinska University Hospitla
Stockholm, Sweden Recruiting -
Karolinska
Stockholm, Sweden Recruiting
Study contacts
- Principal investigator: Eva M Pontén, MD PhD — Karolinska Institutet
- Study coordinator: Eva M Pontén, MD PhD
- Email: eva.ponten@ki.se
- Phone: +46706303052
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This study looks at whether individualized multisite upper limb surgery helps improve hand function in kids with hemiplegic cerebral palsy, using each child as their own control before and after surgery.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.