Measuring muscle characteristics in patients with cerebral palsy
Exploration of the Length/Tension Relationship in Spastic Muscle in Vivo and Its Relation to the Muscle's Macromolecular Composition. The Results Are Related to Function Before and After Tendon Transfer/Tendon Lengthenings.
This study is testing a new way to measure muscle characteristics in people with cerebral palsy to see how muscle tightness and stiffness change as they get older, which could help improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 2 Years to 18 Years |
| Sex | All |
| Sponsor | Region Stockholm Government |
| Locations | 3 sites (Stockholm and 2 other locations) |
| Trial ID | NCT05518565 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with cerebral palsy (CP) to investigate muscle characteristics, specifically sarcomere length, using a novel in vivo measurement technique. The study aims to understand how muscle contracture and spasticity affect the limbs of individuals with CP, particularly as they age. By utilizing laser diffraction to analyze muscle biopsies, researchers hope to gain insights into the optimal surgical interventions needed to improve muscle function and joint positioning. The findings could inform better treatment strategies for managing muscle shortening and related complications in CP.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with cerebral palsy or acquired brain injury.
Not a fit: Patients with progressive neurological diseases will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved surgical techniques and treatment plans for patients with cerebral palsy, enhancing their mobility and quality of life.
How similar studies have performed: While the approach of measuring sarcomere length in vivo is innovative, similar studies have shown promise in understanding muscle dynamics in other conditions, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Celebral Palsy or Aquired Brain Injury Exclusion Criteria: * Progressive neurological disease
Where this trial is running
Stockholm and 2 other locations
- Karolinska University Hospital — Stockholm, Sweden (Recruiting)
- Karolinska University Hospitla — Stockholm, Sweden (Recruiting)
- Karolinska — Stockholm, Sweden (Recruiting)
Study contacts
- Principal investigator: Eva M Pontén, MD PhD — Karolinska Institutet
- Study coordinator: Eva M Pontén, MD PhD
- Email: eva.ponten@ki.se
- Phone: +46706303052
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.