Clinical trial Recruiting at 3 sites Observational Ages 2 to 18

Measuring muscle characteristics in patients with cerebral palsy

Official title: Exploration of the Length/Tension Relationship in Spastic Muscle in Vivo and Its Relation to the Muscle's Macromolecular Composition. The Results Are Related to Function Before and After Tendon Transfer/Tendon Lengthenings.

Run by Region Stockholm · NCT05518565 · Data updated 2026-11-12

This study is testing a new way to measure muscle characteristics in people with cerebral palsy to see how muscle tightness and stiffness change as they get older, which could help improve treatment options.

More Cerebral Palsy trials

Quick facts

Study typeObservational
Ages2 Years to 18 Years
SexAll
Enrollment150 (estimated)
SponsorRegion Stockholm
Government
Locations3 sites (Stockholm and 2 other locations)
StatusRecruiting
StartedJanuary 15, 2002
Main results expectedDecember 15, 2032
Study endsDecember 15, 2033
Registry record updatedAugust 26, 2022
Trial IDNCT05518565 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals diagnosed with cerebral palsy or acquired brain injury.

Probably not a fit

Patients with progressive neurological diseases will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with cerebral palsy (CP) to investigate muscle characteristics, specifically sarcomere length, using a novel in vivo measurement technique. The study aims to understand how muscle contracture and spasticity affect the limbs of individuals with CP, particularly as they age. By utilizing laser diffraction to analyze muscle biopsies, researchers hope to gain insights into the optimal surgical interventions needed to improve muscle function and joint positioning. The findings could inform better treatment strategies for managing muscle shortening and related complications in CP.

Why it matters

Potential benefit: If successful, this study could lead to improved surgical techniques and treatment plans for patients with cerebral palsy, enhancing their mobility and quality of life.

How similar studies have gone: While the approach of measuring sarcomere length in vivo is innovative, similar studies have shown promise in understanding muscle dynamics in other conditions, suggesting potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Celebral Palsy or Aquired Brain Injury

Exclusion Criteria:

* Progressive neurological disease

Where it's running

  • Karolinska University Hospital
    Stockholm, Sweden
    Recruiting
  • Karolinska University Hospitla
    Stockholm, Sweden
    Recruiting
  • Karolinska
    Stockholm, Sweden
    Recruiting

Study contacts

  • Principal investigator: Eva M Pontén, MD PhD — Karolinska Institutet
  • Study coordinator: Eva M Pontén, MD PhD
  • Email: eva.ponten@ki.se
  • Phone: +46706303052

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.