Measuring liver blood flow in healthy children using ultrasound
Ultrasound Measurements of Hepatic Vasculatures and Hepatic Doppler Assessment of Healthy Children
Hong Kong Children's Hospital · NCT04619966
This study is trying to find out what normal liver blood flow looks like in healthy children by using ultrasound to measure different blood vessels in the liver.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 1 Day to 18 Years |
| Sex | All |
| Sponsor | Hong Kong Children's Hospital (other) |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT04619966 on ClinicalTrials.gov |
What this trial studies
This observational study aims to establish normal ranges for the sizes and flow patterns of the hepatic vasculature in children, taking into account factors such as age, weight, height, and gender. Participants will undergo clinically indicated ultrasound examinations, followed by additional Doppler assessments of the hepatic artery, hepatic vein, and portal vein. The study will utilize a Philips EPIQ 5G ultrasound machine to gather quantitative and qualitative data on liver blood flow dynamics. The findings will help create a robust reference for normal liver measurements in pediatric patients.
Who should consider this trial
Good fit: Ideal candidates are children aged 18 years or younger without any history of hepatobiliary or cardiac diseases.
Not a fit: Patients over 18 years of age or those with known hepatobiliary or cardiac pathologies will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide essential reference values for diagnosing liver-related conditions in children.
How similar studies have performed: While there is existing literature on liver measurements, this study aims to provide a more comprehensive and age-corrected normal range, making it a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patient \< / = 18 years of age. 2. No history of hepatobiliary nor cardiac pathology as checked with record in ePR. Verbal confirmation will be done with patient or parent / legal guardian. 3. Attending USG study other than that of the hepatobiliary system. (ie. Patients attending for thyroid USG, urinary system USG, musculoskeletal system USG etc.) Exclusion Criteria: 1. Patient \> 18 years of age 2. Known history of hepatobiliary or cardiac pathology. 3. Unstable patients. 4. Intolerance of USG examination 5. Uncooperative patients. 6. Patient requiring sedation for USG study.
Where this trial is running
Hong Kong
- Hong Kong Children's Hospital — Hong Kong, Hong Kong (RECRUITING)
Study contacts
- Principal investigator: Pui Kwan Joyce Chan, MBChB — Hong Kong Children's Hospital
- Study coordinator: Pui Kwan Joyce Chan, MBChB
- Email: cpk706@ha.org.hk
- Phone: +85296362929
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Portal Vein, Hepatic Veins, Hepatic Artery, Liver Circulation