Measuring intracranial pressure using non-invasive eye scans

Estimation of Intracranial Pressure Using Non-invasive Fundus Videos

Observational Odense University Hospital · NCT03382860

This study is trying to see if a new eye scan can safely measure brain pressure without the need for surgery, helping patients with neurological conditions.

Quick facts

Study typeObservational
Enrollment50 (estimated)
Ages18 Years and up
SexAll
SponsorOdense University Hospital Academic / other
Locations1 site (Odense C, Danmark)
Trial IDNCT03382860 on ClinicalTrials.gov

What this trial studies

This pilot study aims to evaluate the ability to detect intracranial pressure (ICP) through a non-invasive retinal fundus scanner that captures images of the eye's vessels. By measuring the diameter of the arteries and veins, a ratio is calculated and compared to traditional ICP monitoring methods, such as fiberoptic intraparenchymal and intraventricular monitoring. The goal is to develop a safer, non-surgical method for monitoring ICP, which currently relies on invasive techniques that carry risks of complications. This study could pave the way for improved patient care in neurosurgery and neurology.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older who require ICP monitoring and are conscious and able.

Not a fit: Patients who are disabled, unconscious, or do not require ICP monitoring will not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could provide a safer, non-invasive method for monitoring intracranial pressure in patients.

How similar studies have performed: While non-invasive methods for ICP monitoring are currently lacking, this study represents a novel approach that has not been extensively tested in similar contexts.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults 18 years or older with indication for intraparenchymal or intraventricular ICP monitoring
* Conscious and able
* Admission to the Department of Neurosurgery or Department of Neurology at Odense University Hospital

Exclusion Criteria:

* Disabled and unconscious
* No intraparenchymal or intraventricular ICP monitoring

Where this trial is running

Odense C, Danmark

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Intracranial PressureIntracranial HypertensionIntracranial pressure monitoringNon-invasive point-of-care deviceNormal pressure hydrocephalus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.