Measuring heart function in women with preeclampsia
Coload Effect on Cardiac Output Measurement Using Transthoracic Echocardiography in Preeclamptic Patients Undergoing Cesarean Delivery
NA · Mansoura University · NCT05435573
This study tests how different fluids affect heart function in pregnant women with preeclampsia to better understand their heart health during pregnancy.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 34 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Mansoura University (other) |
| Locations | 1 site (Mansoura) |
| Trial ID | NCT05435573 on ClinicalTrials.gov |
What this trial studies
This study investigates the cardiac output in pregnant women diagnosed with preeclampsia using transthoracic echocardiography, a non-invasive method for assessing heart function. Participants will receive a series of fluid interventions, including ringer's acetate solution and hydroxyethyl starch, to evaluate their effects on cardiac performance. The study aims to understand the cardiovascular changes that occur during preeclampsia and how these changes can be monitored effectively. By focusing on women scheduled for elective cesarean delivery under spinal anesthesia, the study seeks to provide insights into managing hypertensive disorders in pregnancy.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 18-45 years with a diagnosis of preeclampsia who are scheduled for elective cesarean delivery.
Not a fit: Patients who are underweight, obese, in labor, or have other significant health issues such as diabetes or cardiovascular diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the management of cardiovascular health in pregnant women with preeclampsia, leading to better outcomes for both mothers and infants.
How similar studies have performed: While there is existing research on cardiac function in pregnancy, this specific approach using echocardiography in preeclamptic patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pre-eclampsia * Age 18-45 years. * Singleton pregnancy scheduled for elective CS delivery under spinal anesthesia. * American Society of Anesthesiologists (ASA Ⅱ, Ⅲ). Exclusion Criteria: * Body mass index \< 18 or ≥40 kg/m² * Women presenting in labor * Current administration of vasoactive drugs including salbutamol and thyroxin. * Diabetes mellitus. * Hemoglobin \<10 g/dl. * Cardiovascular, cerebrovascular, or renal disease * Increased serum creatinine level ≥1.1 mg/dL. * Contraindications to spinal anesthesia:(increased intracranial pressure, coagulopathy, or local skin infection)
Where this trial is running
Mansoura
- Mansoura University-Emergency hospital-ICU — Mansoura, Egypt (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Echocardiography