Measuring eye blood flow and retinal oxygen use in people with diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study will use noninvasive imaging—laser speckle flowgraphy (LSFG), optical coherence tomography (OCT), and OCT angiography (OCT‑A)—to measure ocular blood flow and retinal oxygen extraction in people with diabetes before and after initiation of a GLP‑1 receptor agonist or a dual GIP/GLP‑1 agonist. Eligible participants are adults with diagnosed diabetes who plan to start semaglutide, liraglutide, or tirzepatide and who have no major ocular abnormalities that would prevent reliable imaging. Key exclusions include prior laser photocoagulation in the study eye and recent participation in other trials or clinically relevant illness. All imaging and visits take place at the Medical University of Vienna.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women aged ≥ 18 years
* Signed informed consent
* Previously diagnosed diabetes mellitus
* Normal ophthalmic findings except diabetic retinopathy, unless the investigator considers an abnormality to be clinically irrelevant
* Planned initiation of therapy with GLP-1 receptor agonist (Semaglutide, Ozempic®; Liraglutide, Victoza®) or GIP/GLP-1 receptor agonist (Tirzepatide, Mounjaro®) by a diabetes specialist

Exclusion Criteria:

* Participation in a clinical trial in the 3 weeks preceding the screening visit
* Symptoms of a clinically relevant illness in the 3 weeks before the first study day
* Presence or history of a severe medical condition, except diabetes, as judged by the clinical investigator
* Abuse of alcoholic beverages
* Blood donation during the previous three weeks
* Presence of any abnormalities preventing reliable measurements in the study eye as judged by the investigator
* Previous laser photocoagulation treatment in the study eye
* Best corrected visual acuity \< 0.4 Snellen
* Women of childbearing potential (neither menopausal, nor hysterectomized, nor sterilized) not using effective contraception
* Pregnancy, planned pregnancy or lactation

Where it's running

• Medical University Vienna
  Vienna, State of Vienna, Austria Recruiting

Study contacts

• Study coordinator: Doreen Schmidl, Prof. Priv. Doz. MD.; PhD
• Email: doreen.schmidl@meduniwien.ac.at
• Phone: +431404002981

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.