Measuring extracellular water to define volume status in sepsis
Phenotypes in Sepsis - Extracellular Water for Volume Status Characterization
This project will test whether measuring extracellular water helps describe volume status in adults with sepsis and unstable blood pressure.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Uppsala University Academic / other |
| Locations | 1 site (Uppsala, Uppsa) |
| Trial ID | NCT06512129 on ClinicalTrials.gov |
What this trial studies
This is an observational study enrolling adult sepsis patients admitted to intensive care where extra non-invasive monitoring is added to routine care. During the first three days after inclusion, researchers will collect blood samples and perform extended monitoring including extracellular water measurement with the MoistureMeterD and microcirculation imaging with the CytoCam. No experimental treatments are given; data from these measurements will be compared to standard hemodynamic assessments to see how extracellular water relates to volume status. The aim is to determine whether these added, bedside measurements provide useful information about fluid balance in hemodynamically unstable septic patients.
Who should consider this trial
Good fit: Adults admitted to the participating ICUs with sepsis and hemodynamic instability who are not pregnant and do not have a known non-septic cause of shock are the intended candidates.
Not a fit: Patients who are hemodynamically stable, those without sepsis, pregnant patients, or patients whose shock has a known non-septic cause are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this approach could improve bedside recognition of fluid status and support more tailored fluid management in septic patients.
How similar studies have performed: Related techniques like bioimpedance-based extracellular water measurement and microcirculation imaging have shown promise in other settings, but their specific value for guiding volume status in sepsis remains incompletely established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults with sepsis. Exclusion Criteria: * Pregnancy, other than sepsis known cause of shock.
Where this trial is running
Uppsala, Uppsa
- AnOpIva — Uppsala, Uppsa, Sweden (Recruiting)
Study contacts
- Principal investigator: Annelie Barrueta Tenhunen, MD, PhD — Uppsala University, Region Uppsala
- Study coordinator: Annelie Barrueta Tenhunen, MD, PhD
- Email: annelie.barrueta@uu.se
- Phone: +46728881882
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.