Measuring disease markers in fluid from odontogenic cysts
Official title: Measurement of MMP-8, MMP-9, RANKL, MIP-1alpha in Biopsy Samples From Odontogenic Cyst Patients
Run by Harran University · NCT07171151 · Data updated 2026-11-12
This will test whether measuring MMP-8, MMP-9, RANKL, and MIP-1α in fluid taken during routine puncture from people with odontogenic cysts can help explain how those cysts form.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 12 Years to 80 Years |
| Sex | All |
| Enrollment | 25 (estimated) |
| Sponsor | Harran University Academic / other |
| Locations | 1 site (Sanliurfa) |
| Status | Recruiting |
| Started | August 25, 2025 |
| Main results expected | December 2025 |
| Study ends | May 2026 |
| Registry record updated | September 12, 2025 |
| Trial ID | NCT07171151 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients with odontogenic cysts who will undergo routine puncture and subsequent enucleation or marsupialization at Harran University, who are not pregnant or breastfeeding and can give informed consent.
✕Probably not a fit
Patients who are pregnant, breastfeeding, taking oral contraceptives, systemically unfit for surgery, or who will not undergo cyst puncture/biopsy are unlikely to receive direct benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational project will enroll about 25 patients with clinically and radiologically identified odontogenic cystic lesions presenting to Harran University between August and December 2025. Cyst fluid will be aspirated during routine puncture before enucleation or marsupialization, centrifuged, stored at -80 °C, and later analyzed by ELISA for MMP-8, MMP-9, RANKL and MIP-1α. Biomarker concentrations will be compared across cyst types and between inflammatory versus developmental origins and correlated with clinical features. Data will be analyzed in SPSS with normality testing (Shapiro–Wilk, Kolmogorov) and appropriate statistical comparisons.
Why it matters
Potential benefit: If successful, the findings could improve understanding of how odontogenic cysts form and identify biomarkers that aid diagnosis or guide future targeted therapies.
How similar studies have gone: Prior studies have measured MMPs and RANKL in odontogenic lesions and related jaw cysts with mixed but informative results, so the biomarker approach has precedent though findings remain variable.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Individuals diagnosed with cysts 2. Individuals who are not pregnant or breastfeeding 3. Individuals who agree to sign the informed consent form Exclusion Criteria: 1. Systemically ill individuals who are contraindicated for surgery. 2. Individuals who do not wish to sign the informed consent form. 3. Individuals who are pregnant, breastfeeding, or using oral contraceptives will be excluded.
Where it's running
-
Harran University, Faculty of Dentistry
Sanliurfa, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: hande has elci — Harran University
- Study coordinator: mine alkaya karagoz
- Email: minekaragoz@harran.edu.tr
- Phone: 905365417606
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.