Measuring breathing effort in patients with idiopathic pulmonary fibrosis
Official title: Inspiratory Effort Assessed Through Nasal Pressure Measurement in Patients With Idiopathic Pulmonary Fibrosis
Run by University of Modena and Reggio Emilia · NCT05310669 · Data updated 2026-11-12
This study is trying to see how hard people with idiopathic pulmonary fibrosis have to work to breathe, to better understand how the disease is progressing.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Modena and Reggio Emilia Academic / other |
| Locations | 1 site (Modena) |
| Status | Recruiting |
| Started | July 1, 2023 |
| Main results expected | July 1, 2027 |
| Study ends | July 1, 2030 |
| Registry record updated | February 5, 2026 |
| Trial ID | NCT05310669 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults diagnosed with idiopathic pulmonary fibrosis exhibiting a usual interstitial pneumonia pattern.
✕Probably not a fit
Patients with conditions such as COPD, neuromuscular diseases, or those experiencing acute exacerbations of IPF may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients diagnosed with idiopathic pulmonary fibrosis (IPF) to assess their inspiratory effort through nasal pressure measurements. The research aims to better understand the progression of lung damage in IPF, a condition characterized by severe respiratory failure and a median survival of three years post-diagnosis. By evaluating the inspiratory effort, the study seeks to identify potential correlations with disease progression and acute exacerbations. Participants will undergo radiological evaluations to confirm their diagnosis and suitability for the study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of IPF progression and improve management strategies for patients.
How similar studies have gone: While there have been studies on IPF and its management, this specific approach using nasal pressure measurement is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients treated in Center for Rare diseases of Azienda Ospedaliero-Universitaria Policlinico di Modena will be considered eligible if satisfying the following inclusion criteria: * Patient with IPF and UIP pattern * Need for radiological evaluation through HRCT Exclusione criteria * Age below 18 * Pregnancy * Inability to sign informed consent * COPD * Neuromuscular diseases * Evidence of IPF acute exacerbation
Where it's running
-
Azienda Ospedaliero Universitaria Policlinico di Modena
Modena, Italy Recruiting
Study contacts
- Study coordinator: Roberto Tonelli, MD
- Email: roberto.tonelli@unimore.it
- Phone: +390594225934
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
HOXB7 and related lung and blood biomarkers in pulmonary fibrosis
This pilot study will test whether levels of HOXB7 and other molecules in lung tissue and blood exosomes can serve as biomarkers in adults with pulmonary fibrosis.
-
Rehabilitation counseling for patients with interstitial lung disease
This study is trying to see if rehabilitation counseling can help improve the physical and emotional well-being of patients with idiopathic pulmonary fibrosis.
-
AccuPulmo CT Portal for Detecting Pulmonary Fibrosis on Chest CT
This study tests how well the AccuPulmo CT Portal can identify pulmonary fibrosis on existing chest CT scans from adults at Taichung Veterans General Hospital.
-
Advanced imaging to see how immunosuppression affects lung fibrosis activity
This trial will test whether immunosuppression changes PET and MRI measurements of active collagen deposition and tissue injury in people with non‑IPF interstitial lung disease who are starting treatment.
-
68Ga-NI-FAPI-04 PET/CT imaging to detect fibroblast activation in cancer, fibrotic, and heart diseases
This test will see if an injected PET tracer called 68Ga-NI-FAPI-04 can better show fibroblast activation in people with tumors, pulmonary fibrosis, certain autoimmune vascular diseases, hypertrophic cardiomyopathy, or other cardiovascular conditions.
-
Home monitoring for patients with pulmonary fibrosis
This study tests if using home monitoring and video calls can help people with pulmonary fibrosis manage their condition as well as or better than regular clinic visits.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.