Measuring brain-surface iron with MRI in superficial siderosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project uses quantitative susceptibility mapping (QSM), an MRI method, to quantify iron accumulation on the brain surface in people with infratentorial superficial siderosis and in healthy control participants. Participants will have specialized MRI scans and a battery of clinical tests including hearing evaluations, walking and balance assessments, and cognitive testing. Researchers will compare the MRI-derived iron measurements with symptom severity to see if imaging signals relate to clinical features. All imaging and clinical assessments are conducted on-site at Perspectum in Oxford and are noninvasive apart from standard MRI safety considerations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Superficial siderosis cohort:

* Male or female adults of 18 years of age or older with a confirmed diagnosis of superficial siderosis
* Participants who have the capacity and a level of English proficiency that allows him/her to communicate well with the Investigator, understand and comply with the requirements of the investigation, read all participant facing documentation, as well as read and sign the informed consent form.
* Participants willing and able to give informed consent for participation in the investigation

Healthy cohort:

* Male or female over 18 years of age without a diagnosis of a neurological disorder
* Participants who have the capacity and a level of English proficiency that allows him/her to communicate well with the Investigator, understand and comply with the requirements of the investigation, read all participant facing documentation, as well as read and sign the informed consent form.
* Participants willing and able to give informed consent for participation in the investigation

Exclusion Criteria:

* The participant may not enter the investigation if they have any contraindication to magnetic resonance imaging (including pregnancy, extensive tattoos, pacemaker, shrapnel injury or metallic unfixed implanted devices, metallic fragments, severe claustrophobia and cochlear implants)
* Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the investigation, or may influence the result of the investigation, or the participant's ability to participate in the investigation
* Participants who do not demonstrate the capacity to understand the investigation information or provide informed consent

Where it's running

• Perspectum
  Oxford, United Kingdom Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.