Measuring brain blood flow in children with cerebral arteriopathies using advanced MRI techniques
Measurement of Brain Perfusion by a Magnetic Resonance (MR) Perfusion Imaging Called eASL in Children's Cerebral Arteriopathies.
This study is testing a new MRI technique to see if it can better measure blood flow in the brains of children with certain blood vessel conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | N/A to 18 Years |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Trial ID | NCT05026060 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of a new MR perfusion imaging technique called eASL in measuring cerebral perfusion in children diagnosed with acute or chronic cerebral arteriopathies. The eASL method utilizes multiple post-labeling delays to improve the accuracy of cerebral blood flow measurements, addressing limitations of traditional single-delay ASL sequences. The study will involve children aged 0 to 18 who require diagnostic MR imaging as part of their clinical care. By comparing the eASL technique to standard ASL, the researchers hope to determine its efficacy in assessing cerebral perfusion in this patient population.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 0 to 18 with acute or chronic arterial diseases such as Moya-moya or sickle cell disease.
Not a fit: Patients with usual contraindications to MRI or those who cannot remain still during the imaging sequences may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate assessments of cerebral blood flow in children with arteriopathies, improving diagnosis and treatment planning.
How similar studies have performed: While the eASL technique is relatively novel in this context, previous studies have shown promise in using advanced ASL methods for improved perfusion imaging.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Minor patients aged 0 to 18 with acute or chronic arterial disease: diagnosis of Moya-moya, diagnosis of sickle cell disease, acute and chronic arterial infarction. * Necessity of diagnostic MR with standard ASL sequences for the care. * Holders of parental authority and patients informed and not opposed to their participation in the study. Exclusion Criteria: * Usual contraindications to MR. * Movement during ASL / eASL sequences.
Where this trial is running
Paris
- Hôpital Necker-Enfants Malades — Paris, France (Recruiting)
Study contacts
- Principal investigator: Nathalie BODDAERT, MD, PhD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Nathalie BODDAERT, MD, PhD
- Email: nathalie.boddaert@aphp.fr
- Phone: 1 71 39 65 30
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.