Measuring blood flow in the aorta
Official title: Quantifying Blood Flow in the Aorta Using Phase-Contrast 4D Flow MRI - Phase 2
Run by University of Twente · NCT07577752 · Data updated 2026-11-12
4D-flow MRI will be used to map aortic blood flow in healthy adults to see how flow patterns change with age and gender.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | University of Twente Academic / other |
| Locations | 1 site (Enschede, Overijssel) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | July 31, 2026 |
| Study ends | July 31, 2027 |
| Registry record updated | May 11, 2026 |
| Trial ID | NCT07577752 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults aged 18 or older with BMI ≤ 30, no history of cardiovascular disease, ability to undergo MRI, and capacity to provide informed consent.
✕Probably not a fit
People with known or current cardiovascular disease, irregular heart rhythms, BMI over 30, or standard MRI exclusions (for example pacemakers, cerebral clips, pregnancy, or severe claustrophobia) are unlikely to be eligible or to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational project will obtain PC 4D-flow MRI scans from seventy healthy volunteers to quantify local blood flow in the thoraco-abdominal aorta and primary side branches. A separate MRI sequence will capture the 3D vessel geometry from the ascending aorta down to the internal and external iliac arteries. Participants will also complete a brief questionnaire about age, weight, height, and gender so flow patterns can be related to these factors. Extracted flow measurements and boundary conditions will be used to support future in-vitro and in-silico modelling studies.
Why it matters
Potential benefit: If successful, the work will create detailed baseline maps of normal aortic blood flow that can help researchers and clinicians understand age- and sex-related differences and improve future models and tests.
How similar studies have gone: PC 4D-flow MRI has been successfully used in prior research to map aortic flow in healthy volunteers and patients, so the imaging method is established though this protocol focuses on extracting boundary conditions for modelling.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy (in particular without any cardiovascular disease or history thereof) men or women * 18 years of age or above; * BMI ≤ 30; * Willingness to undergo MRI scans; * Able to provide signed informed consent (IC) Exclusion Criteria: * Irregular heartbeat.; * Any history of cardiovascular disease or current cardiovascular disease; * The standard MRI exclusion criteria (such as pacemakers, cerebral vascular clips, pregnancy, claustrophobia)
Where it's running
-
TechMed centre, University of Twente
Enschede, Overijssel, Netherlands Recruiting
Study contacts
- Principal investigator: Michel M.P.J. Reijnen, prof. dr. — University of Twente
- Study coordinator: Marleen E. Krommendijk, ir.
- Email: m.e.krommendijk@utwente.nl
- Phone: +31534894988
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.