Measuring airway size during and after muscle relaxation in surgery

Measuring Upper Airway Cross Sectional Areas During Residual Neuromuscular Blockade and After Reserval

This study looks at how muscle relaxants during surgery affect the size of the airway in patients to see if they cause any breathing problems after waking up.

Quick facts

• Study type: Observational
• Enrollment: 20 (estimated)
• Ages: 18 Years to 65 Years
• Sex: All
• Sponsor: University of Debrecen (Academic / other)
• Locations: 1 site (Debrecen, Hajdú-Bihar)
• Trial ID: NCT06544980 on ClinicalTrials.gov

What this trial studies

This observational study investigates the relationship between residual neuromuscular blockade and airway cross-sectional areas in patients undergoing surgery. It aims to measure the retroglossal pharyngeal areas before and after extubation, comparing these measurements to assess the impact of muscle relaxants on airway obstruction. The study includes 20 patients and utilizes electromyography to monitor neuromuscular function, focusing on how airway dimensions change with varying degrees of muscle relaxation.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18-65 with normal body weight undergoing surgeries requiring intubation.

Not a fit: Patients with neuromuscular disorders, difficult airways, or those on medications affecting neuromuscular function may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve postoperative care by identifying patients at risk for airway obstruction due to residual neuromuscular blockade.

How similar studies have performed: Previous studies have indicated a correlation between neuromuscular blockade and airway obstruction, suggesting this approach has been explored with some success.

Eligibility criteria

Inclusion Criteria:

Age: 18-65 years;

* ASA 1-3;
* BMI 18.5-25 (normal body weight);
* men/women in equal proportion;
* duration of surgeries at least ≥ 30 minutes;
* intervention requiring intratracheal intubation;
* patients are in a supine position.

Exclusion Criteria:

diseases affecting neuromuscular function (myopathies, severe liver and kidney failure);

* drugs affecting neuromuscular function (magnesium, aminoglycosides);
* difficult airway, expected difficult intubation;
* pregnancy (pregnancy test for women of childbearing age to rule out pregnancy we finish);
* breastfeeding;
* acute surgery;
* COPD
* glaucoma

Where this trial is running

Debrecen, Hajdú-Bihar

• University of Debrecen — Debrecen, Hajdú-Bihar, Hungary (Recruiting)

Study contacts

• Principal investigator: László Asztalos, MD, PhD — Department of Anesthesiology and Intensive Care University of Debrecen
• Study coordinator: László Asztalos, MD, PhD

Conditions Postoperative Residual Curarization; Airway Obstruction on Anaesthetic Emergence; residual neuromuscular blockade; postoperative airway obstruction; electromyography