Measuring a new biomarker in obese children with or without type 2 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to measure blood levels of 1,5-anhydroglucitol in obese children aged 12 to 16 years, both with and without type 2 diabetes. The researchers will correlate these levels with functional beta-cell mass and glucose metabolism parameters, comparing them to healthy volunteers. The goal is to validate 1,5-anhydroglucitol as a novel biomarker for assessing beta-cell function in this population. The study is conducted at the University Hospital of Geneva in collaboration with the Diabetes Center of the Faculty of Medicine, University of Geneva.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children aged 12 to 16 years
* Obesity. Defined as a body-mass index above the 97th percentile.
* Ability to give informed consent as documented by signature

Exclusion Criteria:

* Patients with diabetes mellitus and positive autoantibodies against islets, insulin, islet antigen 2, glutamic acid decarboxylase or Zinc transporter 8.
* Patients with known liver disease (other than NAFLD)
* Patients treated with an oral antidiabetic drug, glucagon-like peptide-1 analogues or insulin at the time of or less than 2 weeks prior to inclusion.
* Patients treated with a drug known to affect liver function

Where it's running

• University Hospital of Geneva
  Geneva, Canton of Geneva, Switzerland Recruiting

Study contacts

• Study coordinator: Philippe Klee
• Email: philippe.klee@unige.ch
• Phone: +41 79 55 33 476

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.