Measurement of Head and Neck Tumor Hypoxia With PET-MRI
Simultaneous PET-MRI for Comparison of Advanced DW-MRI Techniques and EF5-PET in the Detection of Hypoxia in Head and Neck Cancer
This study is testing if a special imaging technique can help doctors see low oxygen levels in head and neck tumors to improve treatment for patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Turku University Hospital Government |
| Drugs / interventions | chemotherapy, immunotherapy |
| Locations | 1 site (Turku, G102881) |
| Trial ID | NCT05246475 on ClinicalTrials.gov |
What this trial studies
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Who should consider this trial
Good fit: Unknown
Not a fit: Unknown
Why it matters
Potential benefit: Unknown
How similar studies have performed: Unknown
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 18 to 80 years old * Sex: male or female * Language spoken: Finnish or Swedish * Performance status: Karnofsky score 70 or better or WHO performance status 2 or better * Mental status: Patients must be able to understand the meaning of the study * Diagnosis: Histological, cytological and clinical findings are consistent with squamous cell carcinoma of the head and neck (oral cavity, pharynx or larynx) * Primary tumor diameter as determined clinically or from contrast enhanced CT or MRI scan must be at least 20 mm * Patients with nodal neck metastases of head and neck cancer are eligible * Informed consent: The patient must sign the appropriate Ethical Committee (EC) approved informed consent documents in the presence of the designated staff * Gravidity: Patient, if female, must not be pregnant or lactating at the time of the study Exclusion Criteria: * Any previously known contraindication of MR Imaging (including but not limited to metallic implants or foreign bodies, pacemakers or other cardiac implantable electronic devices, MR-incompatible prosthetic heart valves, contrast allergy, claustrophobia) * Prior Medical History: Patient must have no history of serious haematologic, cardiovascular, liver or kidney disease. Since none of these is an absolute contraindication for inclusion final judgement will be left to the investigators. * Prior Therapy: Patient must have no history of previous chemotherapy, biological therapy, immunotherapy, radiotherapy or major surgery for treatment of head and neck cancer * Infections: Patient must not have an uncontrolled serious infection * Advanced disease: Patient is not eligible for curative cancer treatment due to advanced disease.
Where this trial is running
Turku, G102881
- Turku University Hospital — Turku, G102881, Finland (Recruiting)
Study contacts
- Principal investigator: Jussi Hirvonen, MD, PhD — Radiologist
- Study coordinator: Jussi Hirvonen, MD, PhD
- Email: jussi.hirvonen@tyks.fi
- Phone: 0035823130000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions
Head and Neck Cancer
Last reviewed 2026-06-13 by the Find a Trial editorial team.
Information on this page is for educational purposes and is not medical advice.
Always consult qualified healthcare professionals about clinical trial participation.