MatriDerm® nerve wrap to repair cut sensory nerves in the hand and fingers.
Official title: Nerve Grafting Using MATRIderm® in Traumatic Digital Nerve Injuries: a Randomized, Single-center, Controlled Study
Run by Centre Hospitalier Universitaire de Nice · NCT07292415 · Data updated 2026-11-12
We will try wrapping a stitched hand or finger sensory nerve with MatriDerm® to see if it improves healing and reduces scarring for people aged 16–75 with traumatic nerve injuries.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 16 Years to 75 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice, Alpes Maritimes) |
| Status | Recruiting |
| Started | February 5, 2026 |
| Main results expected | August 5, 2028 |
| Study ends | August 5, 2028 |
| Registry record updated | April 3, 2026 |
| Trial ID | NCT07292415 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people aged 16–75 with palm or finger wounds causing significant sensory nerve loss who are eligible for direct epineural suture repair and can attend a one-year follow-up at CHU de Nice.
✕Probably not a fit
Patients with pre-existing sensory disorders or prior nerve injury in the same hand, active hand infection, known hypersensitivity to bovine proteins, or who are pregnant or breastfeeding are excluded and unlikely to benefit from this procedure.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, single-center controlled trial at CHU de Nice compares standard epineural suture repair to the same repair with a 1 mm MatriDerm® collagen-elastin matrix wrapped along the repaired nerve. Eligible patients are 16–75 years old with palm or finger wounds causing partial (>50%) or total sensory nerve loss that can be directly sutured under regional anesthesia and magnification. Postoperative care may include up to two weeks of immobilization if needed, and patients are followed clinically with a key visit at one year to measure sensation, pain, and neuroma or scarring outcomes. The study measures whether adding MatriDerm® improves sensory recovery and reduces painful neuroma formation compared with standard repair.
Why it matters
Potential benefit: If successful, MatriDerm® wrapping could improve sensory recovery and reduce painful neuromas and scar-related problems after repaired digital nerve injuries.
How similar studies have gone: MatriDerm® is well established for skin and soft-tissue reconstruction and some preclinical and early clinical work supports collagen matrices for nerve support, but using MatriDerm® specifically as a nerve wrap is relatively novel with limited clinical evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patient aged 16 to 75 2. Patient with a palm or finger wound with sensory nerve damage (partial \>50% or total) 3. Indication for repair by direct suture in the operating room 4. Possibility of attending a follow-up visit after 1 year 5. Patient affiliated with a social security system 6. Patient who has given their written consent after receiving written and oral information Exclusion Criteria: 1. Pre-existing sensory disorders 2. History of nerve damage in the affected hand 3. Known hypersensitivity to bovine proteins 4. Active infection in the affected hand 5. Patient protected by law under guardianship or curatorship, or unable to participate in a clinical study MATRINERVE 24-PP-12 Version No. 1.0 dated July 22, 2025 Page 8 of 40 clinical trial under Article L. 1121-16 of the French Public Health Code 6. Pregnant or breastfeeding women of childbearing age
Where it's running
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CHU de Nice
Nice, Alpes Maritimes, France Recruiting
Study contacts
- Study coordinator: Olivier CAMUZARD, Pr
- Email: camuzard.o@chu-nice.fr
- Phone: 4 92 03 36 62
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.