Maternal thyroid function and anxiety in high-risk pregnancies and their links to fetal heart activity
Official title: Association Between Maternal Thyroid Functions, Anxiety Levels, and Fetal Cardiotocography Parameters in High-Risk Pregnancies
Run by Istanbul Training and Research Hospital · NCT07774949 · Data updated 2026-11-12
This study will see if maternal thyroid levels and anxiety levels relate to how a fetus’s heart responds during a routine NST in pregnancies at high risk.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 150 (estimated) |
| Sponsor | Istanbul Training and Research Hospital Government |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | March 27, 2026 |
| Main results expected | April 2028 |
| Study ends | December 2028 |
| Registry record updated | August 19, 2026 |
| Trial ID | NCT07774949 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Pregnant individuals with singleton gestations at 32 weeks or later, classified as high-risk and receiving routine thyroid testing and NST in the perinatology clinic, aged 18–45.
✕Probably not a fit
Patients outside the 32 weeks or later window or with multiple pregnancies, acute obstetric conditions, or current psychiatric treatment may not experience any study-derived benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study enrolled pregnant women at 32 weeks or later who are managed as high-risk in a perinatology clinic. Researchers will collect routine thyroid test results (TSH and free T4) and assess maternal anxiety using the Beck Anxiety Inventory, alongside a standard 20-minute non-stress test of the fetus. They will analyze how maternal thyroid status and anxiety relate to fetal cardiotocography parameters such as baseline heart rate, accelerations, reactivity, and decelerations, while considering sociodemographic and obstetric factors. The goal is to identify associations that might help understand fetal well-being in high-risk pregnancies. No interventions are being tested; the study is observational and relies on routine clinical data and non-invasive fetal monitoring.
Why it matters
Potential benefit: If associations are found, clinicians may better interpret fetal monitoring in relation to maternal thyroid status and anxiety in high-risk pregnancies.
How similar studies have gone: Prior work has explored links between maternal thyroid function, anxiety, and fetal monitoring in various contexts, but this specific combination in high-risk pregnancies is exploratory and adds novel observational insight.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Singleton pregnancy at 32 weeks of gestation or later * Pregnancy being followed as a high-risk pregnancy * Age between 18 and 45 years * Availability of routine thyroid function test results and non-stress test assessment * Ability and willingness to provide written informed consent Exclusion Criteria: * Gestational age below 32 weeks * Multiple pregnancy * Fetal conditions that may affect interpretation of the non-stress test tracing * Acute maternal infection * Presence of an acute obstetric condition * Previously diagnosed psychiatric disorder * Current use of psychiatric medication * Age younger than 18 years or older than 45 years
Where it's running
-
Istanbul Training and Research Hospital
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Doruk C Katlan
- Email: dcek2000@yahoo.com
- Phone: +905353475411
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.