Markers of thinking and memory decline after spontaneous brain hemorrhage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study will recruit about 118 adults with spontaneous intracerebral hemorrhage and follow them for one year. Participants will receive cognitive testing during hospitalization and at 3, 6, and 12 months, brain MRI at hospitalization and 12 months, and blood draws at the same timepoints to measure inflammatory markers including suPAR. Investigators will compare patients with and without silent brain infarcts to see differences in baseline cognition, rate of cognitive decline, white matter hyperintensity volume progression using a novel 3-T MRI analysis, and systemic inflammation. The goal is to determine whether silent brain infarcts and suPAR are early, clinically useful biomarkers of vascular contributions to cognitive impairment after ICH.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Primary Intracerebral Hemorrhage
* Age ≥ 18 and \< 80 years

Exclusion Criteria:

* Pre-existing dementia

Where it's running

• Rush University Medical Center
  Chicago, Illinois, United States Recruiting

Study contacts

• Principal investigator: Rajeev Garg, MD — Rush University Medical Center
• Study coordinator: Amanda Sremac, BS
• Email: Amanda_C_Sremac@rush.edu
• Phone: 312-942-0593

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.