Mapping lymph nodes in oropharyngeal cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates a new imaging and surgical protocol for identifying sentinel nodes in patients with oropharyngeal cancer, aiming to improve treatment decisions. It involves a two-stage process where a radioactive tracer is injected into the tumor to enhance the accuracy of sentinel node biopsy. By determining whether cancer has spread to the other side of the neck, the study seeks to reduce unnecessary treatments and their associated side effects. The study is conducted across multiple centers to validate the effectiveness of this new approach compared to the current gold standard.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 or over
* New diagnosis of OPC - all anatomical subsites and HPV status accepted
* Unilateral metastatic nodes equating to AJCC TNM8 clinical staging N1-N2b for P16 negative and N1 for P16 positive patients.

Exclusion Criteria:

* Suspicious bilateral nodes on imaging
* Previous radiotherapy or surgery to the neck
* Second primary oropharyngeal tumours
* Distant metastasis (e.g. lung, bone)
* Pregnancy and lactation
* Inability to give informed consent
* Allergy to lymphatic tracers

Where it's running

• St George's University Hospitals NHS Foundation Trust
  London, United Kingdom Recruiting
• University College Hospital
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Clare Schilling — University College, London
• Study coordinator: Trial Manager
• Email: ncita.looc@ucl.ac.uk
• Phone: 02076799274

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.