Mapping energy metabolism in human muscle and brain using MRI

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop a noninvasive method for quantifying and imaging energy metabolism in human muscle and brain using clinical MRI scanners. The focus is on phosphocreatine (PCr), a key energy metabolite that can be selectively imaged without the use of contrast agents. By utilizing chemical exchange saturation transfer (CEST) MRI, the study seeks to enhance the sensitivity of detecting PCr and quantify its concentration, which is crucial for understanding cellular energy homeostasis. The approach is designed to provide clinically acceptable spatial resolution and scan time, addressing a significant gap in current diagnostic capabilities.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Subject must be at least 18 years of age Subject must be willing and able to undergo verbal and written informed consent Healthy subjects will have no history of cardiovascular or peripheral vascular disease, diabetes, claudication or difficulty walking.

Exclusion Criteria:

1.) Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent, 2.) Contraindications to MRI such (eg implanted metallic objects) 3.) Significant cardiovascular (heart failure, significant coronary artery disease, infiltrative or hypertrophic cardiomyopathy, constrictive pericarditis), pulmonary or musculoskeletal or orthopedic disease that significantly limit exercise capacity 4.) Weight greater than 350 lbs (inability to fit in the MRI), 5.) Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting. 6) Subjects with rest pain, critical limb ischemia will be excluded for the study. 7) Pregnant women

Where it's running

• F. M. Kirby Center and Johns Hopkins University Medical School
  Baltimore, Maryland, United States Recruiting

Study contacts

• Study coordinator: Jiadi Xu, Ph.D.
• Email: xuj@kennedykrieger.org
• Phone: 4105980920

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.