Mapping brain structures related to migraine disorders
Brainstem Mapping of Nociceptive and Non-nociceptive Trigeminal Input and Its Functional Connectivty
This study is testing how the brain reacts to stimulation of the trigeminal nerve in people with migraines to better understand the brain structures involved in their pain.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Universitätsklinikum Hamburg-Eppendorf Academic / other |
| Locations | 1 site (Hamburg) |
| Trial ID | NCT06535880 on ClinicalTrials.gov |
What this trial studies
This study aims to investigate the brain's response to trigeminal nerve stimulation by using BOLD-fMRI imaging. It will scan the entire brain, brainstem, and upper spinal cord during both nociceptive and non-nociceptive electrical stimulation of the trigeminal nerve branches. The research builds on previous findings regarding the clustering of trigeminal nerve branches and seeks to explore higher cortical structures and subnuclei of the spinal trigeminal nucleus that were not previously examined. The study will involve preprocessing and processing of MR data based on established methodologies from prior publications.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy individuals who are suitable for MRI and do not have any headache disorders.
Not a fit: Patients with existing headache diseases, psychological disorders, or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of migraine mechanisms and lead to improved treatment strategies for patients suffering from migraine disorders.
How similar studies have performed: Previous studies have shown promising results in mapping brain structures related to trigeminal nerve stimulation, indicating that this approach has potential for further exploration.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthy * suitable fo MRI Exclusion Criteria: * headache disease * psychological disorder * pregnancy * all exclusion criteria necessary for imaging in a 3 T MRI scanner
Where this trial is running
Hamburg
- University Medical Center Hamburg-Eppendorf — Hamburg, Germany (Recruiting)
Study contacts
- Study coordinator: Arne May, Prof
- Email: a.may@uke.de
- Phone: +4940741059189
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.