Clinical trial Recruiting at 1 site Interventional Ages 30 to 50

Mapping brain functions using electric stimulation during surgery

Official title: Pilot Study: Measure of the Potential Evoked With Electroencephalography and Electrocorticography by Electric Stimulation of the Brain During the Neurosurgery Awakened of the Infiltrative Glioma of Low Grade (OMS Type II)

Run by University Hospital, Montpellier · NCT02509442 · Data updated 2026-11-12

This study is testing how electric impulses during awake surgery for brain tumors can help us understand which parts of the brain are affected and how they work.

Quick facts

Study typeInterventional
Ages30 Years to 50 Years
SexAll
Enrollment12 (estimated)
SponsorUniversity Hospital, Montpellier
Academic / other
Locations1 site (Montpellier)
StatusRecruiting
StartedJuly 22, 2015
Main results expectedOctober 22, 2027
Study endsNovember 2027
Registry record updatedSeptember 29, 2025
Trial IDNCT02509442 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients diagnosed with low-grade infiltrative gliomas who are undergoing their first awake surgery.

Probably not a fit

Patients with significant neurological or psychiatric disorders, or those with a history of severe cranial trauma, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how electric impulses delivered during awake surgery for low-grade infiltrative gliomas affect brain function. Twelve patients will undergo surgery at the CHU of Montpellier, where their brain activity will be monitored using electroencephalography and electrocorticography before and after tumor resection. The goal is to analyze the propagation of these electric impulses and identify the neural networks that are inhibited. Data will be processed and analyzed using specialized software to enhance our understanding of brain function mapping.

Why it matters

Potential benefit: If successful, this study could improve surgical outcomes and functional preservation for patients with low-grade gliomas.

How similar studies have gone: Other studies utilizing direct electric stimulation for brain mapping have shown promising results, indicating potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patient carrier of a low-rank infiltrative glioma (OMS Type II) and presenting the indications to benefit from a surgical care in condition awakened for the first time.
* Patient capable of understanding the nature, the purpose and the methodology of the research.
* Having signed an informed consent writes before the inclusion in the research.
* Membership or beneficiary of a national insurance scheme

Exclusion Criteria:

* Systematic pathology with neurological appearance
* Psychiatric disorders
* History of psychotic disorders
* History of cranial trauma serious (according to the classification), previous or evolutionary other neurological pathology
* Major protected by the law (supervision or guardianship)
* Loss of liberty by court or administrative order

Where it's running

  • CHU de Montpellier - Service de neurochirurgie
    Montpellier, France
    Recruiting

Study contacts

  • Principal investigator: Hugues DUFFAU, Professor — Department of neurosurgery, Hospital Gui de Chauliac, Montpellier
  • Study coordinator: BARBAS Sandrine
  • Email: s-barbas@chu-montpellier.fr

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.