Mapping brain functions using electric stimulation during surgery
Pilot Study: Measure of the Potential Evoked With Electroencephalography and Electrocorticography by Electric Stimulation of the Brain During the Neurosurgery Awakened of the Infiltrative Glioma of Low Grade (OMS Type II)
NA · University Hospital, Montpellier · NCT02509442
This study is testing how electric impulses during awake surgery for brain tumors can help us understand which parts of the brain are affected and how they work.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 12 (estimated) |
| Ages | 30 Years to 50 Years |
| Sex | All |
| Sponsor | University Hospital, Montpellier (other) |
| Locations | 1 site (Montpellier) |
| Trial ID | NCT02509442 on ClinicalTrials.gov |
What this trial studies
This study investigates how electric impulses delivered during awake surgery for low-grade infiltrative gliomas affect brain function. Twelve patients will undergo surgery at the CHU of Montpellier, where their brain activity will be monitored using electroencephalography and electrocorticography before and after tumor resection. The goal is to analyze the propagation of these electric impulses and identify the neural networks that are inhibited. Data will be processed and analyzed using specialized software to enhance our understanding of brain function mapping.
Who should consider this trial
Good fit: Ideal candidates are patients diagnosed with low-grade infiltrative gliomas who are undergoing their first awake surgery.
Not a fit: Patients with significant neurological or psychiatric disorders, or those with a history of severe cranial trauma, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve surgical outcomes and functional preservation for patients with low-grade gliomas.
How similar studies have performed: Other studies utilizing direct electric stimulation for brain mapping have shown promising results, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient carrier of a low-rank infiltrative glioma (OMS Type II) and presenting the indications to benefit from a surgical care in condition awakened for the first time. * Patient capable of understanding the nature, the purpose and the methodology of the research. * Having signed an informed consent writes before the inclusion in the research. * Membership or beneficiary of a national insurance scheme Exclusion Criteria: * Systematic pathology with neurological appearance * Psychiatric disorders * History of psychotic disorders * History of cranial trauma serious (according to the classification), previous or evolutionary other neurological pathology * Major protected by the law (supervision or guardianship) * Loss of liberty by court or administrative order
Where this trial is running
Montpellier
- CHU de Montpellier - Service de neurochirurgie — Montpellier, France (RECRUITING)
Study contacts
- Principal investigator: Hugues DUFFAU, Professor — Department of neurosurgery, Hospital Gui de Chauliac, Montpellier
- Study coordinator: BARBAS Sandrine
- Email: s-barbas@chu-montpellier.fr
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Low Grade Glioma of Brain, mapping brain functions, Direct electric stimulation, potential evoked