Mapping brain blood flow regulation using a new non-invasive device
Official title: Non-Invasive Mapping of Cerebral Autoregulation Using Near Infrared Spectroscopy
Run by University of Manitoba · NCT05433129 · Data updated 2026-11-12
This study is testing a new portable device to see how well it can map blood flow in the brain and how factors like age and sex might change those maps in healthy volunteers.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | University of Manitoba Academic / other |
| Locations | 1 site (Winnipeg, Manitoba) |
| Status | Recruiting |
| Started | July 11, 2023 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | January 6, 2026 |
| Trial ID | NCT05433129 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy volunteers aged 17 and older, regardless of sex.
✕Probably not a fit
Patients with a history of neurological, systemic vascular, or cerebrovascular diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to develop a portable imaging system that utilizes advanced near infrared spectroscopy (NIRS) combined with non-invasive continuous arterial blood pressure monitoring to create cerebral autoregulation (CA) maps of the brain. The study will involve in vivo testing on healthy volunteers to assess the functionality and feasibility of this new system, including various perturbation tests to evaluate its performance. Additionally, the research will explore how aging and sex affect regional differences in cerebral autoregulation using the newly developed platform.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and monitoring of brain blood flow regulation, benefiting patients with conditions related to cerebral autoregulation.
How similar studies have gone: While the approach is innovative, similar studies have shown promise in using non-invasive techniques for cerebral monitoring, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy volunteers (male and female) * Age \> 17 Exclusion Criteria: * History of neurological illness * History of systemic vascular * History of cerebrovascular disease
Where it's running
-
Health Sciences Centre (HSC)
Winnipeg, Manitoba, Canada Recruiting
Study contacts
- Principal investigator: Frederick A Zeiler, MD PhD FRCSC — University of Manitoba
- Study coordinator: Frederick A Zeiler, MD PhD FRCSC
- Email: Frederick.Zeiler@umanitoba.ca
- Phone: +1 (431) 335-7461
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.