Mapping brain blood flow regulation using a new non-invasive device
Non-Invasive Mapping of Cerebral Autoregulation Using Near Infrared Spectroscopy
This study is testing a new portable device to see how well it can map blood flow in the brain and how factors like age and sex might change those maps in healthy volunteers.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Manitoba Academic / other |
| Locations | 1 site (Winnipeg, Manitoba) |
| Trial ID | NCT05433129 on ClinicalTrials.gov |
What this trial studies
This project aims to develop a portable imaging system that utilizes advanced near infrared spectroscopy (NIRS) combined with non-invasive continuous arterial blood pressure monitoring to create cerebral autoregulation (CA) maps of the brain. The study will involve in vivo testing on healthy volunteers to assess the functionality and feasibility of this new system, including various perturbation tests to evaluate its performance. Additionally, the research will explore how aging and sex affect regional differences in cerebral autoregulation using the newly developed platform.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy volunteers aged 17 and older, regardless of sex.
Not a fit: Patients with a history of neurological, systemic vascular, or cerebrovascular diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and monitoring of brain blood flow regulation, benefiting patients with conditions related to cerebral autoregulation.
How similar studies have performed: While the approach is innovative, similar studies have shown promise in using non-invasive techniques for cerebral monitoring, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy volunteers (male and female) * Age \> 17 Exclusion Criteria: * History of neurological illness * History of systemic vascular * History of cerebrovascular disease
Where this trial is running
Winnipeg, Manitoba
- Health Sciences Centre (HSC) — Winnipeg, Manitoba, Canada (Recruiting)
Study contacts
- Principal investigator: Frederick A Zeiler, MD PhD FRCSC — University of Manitoba
- Study coordinator: Frederick A Zeiler, MD PhD FRCSC
- Email: Frederick.Zeiler@umanitoba.ca
- Phone: +1 (431) 335-7461
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.