Mapping brain activity related to movement in Parkinson's disease
Non-invasive Brain Mapping of Movement Facilitation in Parkinson's Disease
This study is testing how different cues can help improve movement in people with Parkinson's disease by looking at their brain activity during movement tasks.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of California, Los Angeles Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT05179187 on ClinicalTrials.gov |
What this trial studies
This study investigates how different types of external cues can help improve movement in patients with Parkinson's disease by using advanced brain mapping techniques. Participants will perform movement tasks while their brain activity is recorded through EEG and MRI to identify the neural circuits involved in movement facilitation. The research aims to understand the brain mechanisms that support improved movements, which could lead to new neuromodulation therapies for symptoms that are difficult to treat, such as freezing of gait. The study will involve 60 patients with Parkinson's disease and 30 healthy controls, with each participant undergoing two sessions of testing.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years old diagnosed with Parkinson's disease exhibiting at least two cardinal features.
Not a fit: Patients with dementia, active hallucinations, or contraindications to MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that significantly improve movement in patients with Parkinson's disease.
How similar studies have performed: Other studies have shown promise in using brain mapping techniques to understand movement disorders, making this approach both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of Parkinson's disease based on presence of at least 2 cardinal features (tremor, rigidity or bradykinesia) OR healthy adult with no neurologic disease * Age \> 18 years old Exclusion Criteria: * Dementia as indicated by score on Montreal Cognitive Assessment \< 19 * Active hallucinations or psychosis * Contraindications to MRI (metal implant, claustrophobia)
Where this trial is running
Los Angeles, California
- University of California Los Angeles — Los Angeles, California, United States (Recruiting)
Study contacts
- Study coordinator: Katy Cross, MD, PhD
- Email: kcross@mednet.ucla.edu
- Phone: 310-206-2828
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.