Mapping and understanding alveolar cells in smokers with COPD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the regenerative abilities of mesenchymal cells in the alveolar type 2 cells of patients undergoing thoracic surgery for suspected cancer. It focuses on smokers with and without chronic obstructive pulmonary disease (COPD) and compares them to non-smokers. The research aims to uncover the mechanisms behind the depletion of alveolar progenitor cells and their role in the pathophysiology of COPD. By analyzing the interactions between different cell populations in the alveolar stem cell niche, the study seeks to provide insights into lung repair processes affected by smoking and COPD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18
2. Patient undergoing lung resection surgery (lobectomy, pneumonectomy, segmentectomy) for cancer or suspected cancer
3. Acceptance to participate in the protocol
4. Affiliated to a social security plan

Exclusion Criteria:

1. Chronic autoimmune disease
2. Patient under guardianship or curators
3. Neo-adjuvant chemotherapy
4. History of thoracic radiotherapy
5. Pregnant woman
6. Minor patient
7. Person not able to consent
8. Person deprived of liberty

Where it's running

• Rousseau-Bussac
  Créteil, France Recruiting
• Hopital Cochin
  Paris, France Active not recruiting
• Hegp
  Paris, France Active not recruiting
• Hopital Tenon
  Paris, France Active not recruiting

Study contacts

• Study coordinator: JUNG Camille, MD
• Email: camille.jung@chiccreteil.fr
• Phone: 0145175000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.