Mandibular stretching and 4-4-8 breathing for autonomic nervous system activity
Official title: Investigation of the Effects of Mandibular Stretching Exercise and 4-4-8 Breathing Exercise on Autonomic Nervous System Activity, Muscle Tone, and Psychological State: A Randomized Controlled Trial
Run by Necmettin Erbakan University · NCT07472010 · Data updated 2026-11-12
This will test whether jaw-stretching and 4-4-8 breathing change nervous system activity, muscle tension, and psychological state in healthy university students.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 30 Years |
| Sex | All |
| Enrollment | 52 (estimated) |
| Sponsor | Necmettin Erbakan University Academic / other |
| Locations | 1 site (Konya, Konya) |
| Status | Recruiting |
| Started | December 15, 2025 |
| Main results expected | March 15, 2026 |
| Study ends | June 19, 2026 |
| Registry record updated | March 16, 2026 |
| Trial ID | NCT07472010 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy university students aged 18–30 who can perform the jaw stretching and 4-4-8 breathing exercises and have no neurological, musculoskeletal, or respiratory disorders or medications affecting the autonomic nervous system.
✕Probably not a fit
People with jaw, neck, or respiratory disorders, neurological disease, or those taking medications that affect autonomic function are unlikely to benefit and are excluded from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial will enroll healthy university students aged 18–30 and randomly assign them to intervention groups involving mandibular stretching, 4-4-8 breathing, or the study protocol's comparison condition. Baseline and post-intervention measurements of autonomic nervous system parameters, muscle tone, and psychological status will be collected. The interventions are non-invasive and performed by participants according to standardized instructions over the intervention period. Study outcomes aim to determine whether these simple exercises produce measurable physiological or psychological changes.
Why it matters
Potential benefit: If successful, these simple, low-cost exercises could offer a non-drug way to improve autonomic balance, reduce muscle tension, and support psychological well-being in young adults.
How similar studies have gone: Prior small studies suggest breathing techniques can alter autonomic markers like heart rate variability, but the combined or comparative effects with mandibular stretching remain largely untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Inclusion Criteria: * Healthy university students * Age between 18 and 30 years * Voluntary participation in the study * Ability to understand and perform mandibular stretching exercise and 4-4-8 breathing exercise Exclusion Criteria: * History of neurological disorders * Musculoskeletal disorders affecting the jaw, neck, or respiratory system * Respiratory diseases * Use of medications that may affect the autonomic nervous system * Inability to perform the exercises required in the study
Where it's running
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Necmettin Erbakan University
Konya, Konya, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Neslihan Altuntaş YILMAZ, PhD — Necmettin Erbakan University
- Study coordinator: Mehin Mammadzada, MSc Student
- Email: mammadzadamehin01@gmail.com
- Phone: +905313124790
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.