Managing heart failure patients at home after hospital discharge

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate whether patients with acute heart failure can effectively manage their condition through digital follow-up at home instead of traditional hospital visits. Patients recently discharged from the hospital will be randomized to receive either digital follow-up or standard outpatient clinic follow-up. The goal is to demonstrate that home-based monitoring and medication adjustments can improve patient outcomes and reduce the burden on healthcare systems. This approach addresses barriers such as travel distance and mobility issues that many patients face when attending hospital appointments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Hospital admission within the 72 hours prior to screening for acute HF.
* NT-proBNP ≥ 1,000 pg/mL measured during the hospitalization
* Systolic blood pressure ≥ 100 mmHg and of heart rate ≥ 60 bpm within 24 hours before randomization
* Serum potassium ≤ 5.0 mEq/L (mmol/L).
* ≤ ½ the optimal dose of ACEi/ARB/ARNi or beta-blocker or MRA.
* Written informed consent to participate in the study.

Exclusion Criteria:

1. Age below 18 or above 85 years.
2. Clearly documented intolerance to high doses of beta-blockers
3. Clearly documented intolerance to high doses of renin-angiotensin system (RAS) blockers (both ACEi and ARB).
4. Renal disease or estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73m2 at screening or history of dialysis.
5. Prior (defined as less than 30 days from screening) or current enrollment in a HF intervention or participation in an investigational drug or device study within the 30 days prior to screening
6. Index event (admission for acute HF) triggered primarily by a completely reversable etiology so that it is unlikely the patient will be classified with chronic HF after discharge, such as Takotsubo syndrome (stress cardiomyopathy). In the setting of acute coronary syndrome or tachycardia, this should be managed before considering the presence of HF. This does not apply to patients with chronic HF prior to the index event.
7. Severe non-adherence to medications
8. Psychiatric or neurological disorder, cirrhosis, or active malignancy leading to a life expectancy less than 6 months.
9. History of heart transplant or on a transplant list, or using or planned to be implanted with a ventricular assist device.
10. Uncorrected thyroid disease, active myocarditis, or known amyloid or hypertrophic obstructive cardiomyopathy.
11. Inability to comply with all study requirements, due to major co-morbidities, social or financial issues, or a history of noncompliance with medical regimens, that might compromise the patients ability to understand and/or comply with the protocol instructions or follow-up procedures.
12. Low digital competency classified as inability to handle a smartphone or tablet.
13. Language barriers requiring the need for an external interpreter.
14. Pregnant or nursing (lactating) women.

Where it's running

• Akershus University Hospital
  Lørenskog, Akershus, Norway Recruiting
• Drammen Hospital, Vestre Viken HF
  Drammen, Vestre Viken, Norway Recruiting
• Sørlandet Sykehus
  Arendal, Norway Recruiting
• Ålesund Hospital
  Ålesund, Norway Recruiting
• Innlandet sykehus
  Hamar, Norway Recruiting
• Levanger Sykehus
  Levanger, Norway Recruiting

Study contacts

• Study coordinator: Peder L Myhre, MD, PhD
• Email: p.l.myhre@medisin.uio.no
• Phone: +47 93025644

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• NT-proBNP–guided heart failure screening for people 65+ in rural China

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• Voice-based detection of heart failure deterioration using Noah Labs Vox

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.