Managing blood pressure during surgery to improve cognitive function in cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled study investigates the effects of different intraoperative blood pressure management strategies on postoperative cognitive function in cancer patients at high risk for stroke. Participants are divided into two groups: one receiving strict blood pressure management to maintain a mean arterial pressure (MAP) of at least 85 mmHg, and the other following conventional management with a MAP of at least 65 mmHg. The study aims to reduce the incidence of delirium and cognitive impairment, as well as serious complications related to blood pressure fluctuations within 30 days post-surgery. A total of 424 subjects are included to ensure robust statistical power.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with high-risk stroke (combined with 3 risk factors or more according to the stroke risk screening table)
2. Patients who plan to undergo surgery for abdominal tumors (gynecological, urinary, hepatobiliary, and gastrointestinal tumors) under general anesthesia are expected to have surgery duration \>2 hours
3. The ASA is rated as Class II or III
4. Patients who underwent invasive arterial blood pressure monitoring before surgery signed informed consent

Exclusion Criteria:

1. Patients do not want to participate in the study
2. Patients with severe heart disease (severe valvular disease, sick sinus syndrome, high atrioventricular block without pacemaker implantation), grade III or above Liver function impairment (Child-Pugh class C)
3. Need kidney replacement therapy; New stroke \<3 months
4. Emergency surgery
5. Preoperative history of mental illness, epilepsy, Parkinson's disease, or myasthenia gravis
6. Speech, vision, or hearing impairment that prevents completion of a cognitive function assessment
7. Situations where strict blood pressure management is not appropriate, such as controlled hypotension during surgery.

Where it's running

• Zhejiang Cancer Hospital
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: yejing Zhu, PHD
• Email: zhuyejing1983@126.com
• Phone: +8618758096745

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.