Management of symptomatic ureteral stones
Official title: Upfront vs Postponed Ureteroscopy (UPURS) Trial for Patient-centered Management of Symptomatic Obstructing Stones
Run by University of California, San Francisco · NCT05715086 · Data updated 2026-11-12
This study tests whether treating ureteral stones right away with a procedure is better than waiting to see if they pass on their own for people who come to the emergency room with this problem.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 2 sites (San Francisco, California and 1 other locations) |
| Status | Recruiting |
| Started | September 6, 2023 |
| Main results expected | December 31, 2030 |
| Study ends | December 31, 2030 |
| Registry record updated | September 15, 2026 |
| Trial ID | NCT05715086 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 years old presenting to the emergency department with a symptomatic ureteral stone of at least 5mm diagnosed via CT scan.
✕Probably not a fit
Patients with strict indications for stenting or those whose stone burden is not amenable to ureteroscopy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial investigates the management of symptomatic ureteral stones by comparing two approaches: upfront ureteroscopy versus observation and delayed intervention. Patients presenting to the emergency department with a ureteral stone will be randomized into one of the two groups. The study aims to address the variability in treatment decisions influenced by factors such as practice setting and insurance status, which can lead to health disparities. By establishing clearer, patient-centered guidelines, the trial seeks to improve care for vulnerable populations.
Why it matters
Potential benefit: If successful, this study could lead to more effective and equitable management of symptomatic ureteral stones.
How similar studies have gone: Other studies have explored similar management strategies for ureteral stones, but this trial aims to provide more definitive patient-centered guidelines.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Presenting to the Emergency Department (ED) * Adult (\> 18 yo) * ≥5mm ureteral stone diagnosed on CT scan * Presence of symptoms (pain, nausea, vomiting, hematuria) Exclusion Criteria: * Strict indication for stent * Stone burden not amenable to Ureteroscopy (URS) * Dirty urine analysis (UA) or positive urine culture (UCx) * Transplant kidney * Presence of conduit * Comorbidities not optimized for surgery * Strong preference for surgery or observation
Where it's running
-
University of Colorado
Aurora, Colorado, United States Recruiting -
University of California, San Francisco
San Francisco, California, United States Terminated
Study contacts
- Study coordinator: Heiko Yang, MD
- Email: HEIKO.YANG@CUANSCHUTZ.EDU
- Phone: 720-848-1800
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.