Management of knee osteoarthritis with surgery
Official title: Evaluation of the Results of High Tibial Osteotomy with or Without Lateral Patellar Facetectomy in Treatment of Combined Patellofemoral and Medial Compartment Knee Osteoarthritis; a Comparative Study
Run by Sohag University · NCT06762171 · Data updated 2026-11-12
This study is testing whether a specific knee surgery can help people with arthritis in their knee feel better and move more easily.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 35 Years to 60 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Sohag University Academic / other |
| Locations | 1 site (Sohag, Sohag Governorate) |
| Status | Recruiting |
| Started | December 1, 2024 |
| Main results expected | June 2025 |
| Study ends | November 2026 |
| Registry record updated | January 7, 2025 |
| Trial ID | NCT06762171 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 35-60 with mild to moderate knee osteoarthritis and specific anatomical criteria.
✕Probably not a fit
Patients with advanced osteoarthritis requiring total knee replacement or those with significant deformities or inflammatory diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of open wedge high tibial osteotomy (OWHTO) in patients with combined patellofemoral and medial compartment knee osteoarthritis. Participants will be randomly assigned to receive either OWHTO with or without arthroscopic partial lateral patellar facetectomy. The surgical procedure involves a thorough examination of the knee joint and potential treatment of any concurrent pathologies. The aim is to assess the outcomes of these surgical interventions in improving knee function and alleviating pain.
Why it matters
Potential benefit: If successful, this approach could significantly improve pain relief and functional outcomes for patients with knee osteoarthritis.
How similar studies have gone: Other studies have shown promising results with similar surgical approaches, indicating potential for success in this trial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 35-60years 2. Mild to moderate TFOA (G I-II-III) Kellgren-Lawrence (KL) scale (16) 3. Anterior knee pain (PFOA) 4. No involvement of the lateral compartment 5. range of motion of at least 120° flexion 6. Body mass index (BMI) \<30kg/m2 7. varus angle degree \<10° Exclusion Criteria: 1. advanced case of TFOA (G VI KL scale), which requires total knee replacement. 2. flexion deformity ≥15° 3. inflammatory disease (such as rheumatoid arthritis).
Where it's running
-
Faculty of medicine, Sohag university
Sohag, Sohag Governorate, Egypt Recruiting
Study contacts
- Study coordinator: Ahmed Tarek Ahmed, Assistant lecturer
- Email: Ahmed.Tarek@med.sohag.edu.eg
- Phone: 01033667677
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Effects of virtual reality on walking in adults with knee osteoarthritis
This study tests how immersive virtual reality environments—designed to feel safe or to provoke fear—affect walking and worry about movement in adults 50 and older with knee osteoarthritis and in healthy peers.
-
Weekly berobenatide for knee osteoarthritis in adults who are overweight or obese
This study tests whether weekly berobenatide helps reduce knee pain and improve function, while also affecting body weight, in adults with knee osteoarthritis who are overweight or obese (with or without type 2 diabetes).
-
Autologous adipose-derived stem cell injections for knee osteoarthritis
We’re testing whether injecting a patient’s own fat-derived stem cells into the knee can help people with knee OA feel less pain and move better, compared with a standard hyaluronic acid treatment.
-
Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty
This study tests whether higher burden of preoperative multimorbidity affects functional recovery after knee replacement in adults with knee osteoarthritis.
-
Cartilage biomarker response to acute loading in knee OA by antiresorptive treatment status
Researchers will test whether a 30-minute treadmill walk changes cartilage biomarkers in postmenopausal women with knee osteoarthritis, comparing those on denosumab, bisphosphonates, and those not on antiresorptives.
-
Lysyl Enzymes in Knee Osteoarthritis
This study tests whether blood levels of lysyl hydroxylase and lysyl oxidase differ between people with knee osteoarthritis and healthy individuals.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.