Magnetic brain stimulation for Alzheimer's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial compares active rTMS with a sham rTMS procedure in people who have biomarker-confirmed mild to moderate Alzheimer's disease. Clinical efficacy and safety will be tracked using cognitive measures and monitoring for adverse events. TMS-EEG and functional near-infrared spectroscopy (fNIRS) will be recorded to probe synaptic plasticity and neurovascular coupling. The study aims to connect any clinical changes to mechanistic signals related to glymphatic regulation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Meets the 2018 NIA-AA diagnostic criteria for Alzheimer's disease (AD)
* Meets DSM-5 diagnostic criteria
* Mild to moderate disease severity (CDR Global Score 1 to 2)
* Evidence of AD pathology: positive amyloid PET OR positive cerebrospinal fluid (CSF) AD biomarkers OR positive plasma AD biomarkers

Exclusion Criteria:

* Contraindications to rTMS treatment
* Severe complications or immune diseases
* Unable to cooperate with study procedures
* History of epilepsy

Where it's running

• rTMS
  Fuzhou, Fujian, China Recruiting

Study contacts

• Study coordinator: Xiaodong Pan
• Email: panxd@fjmu.edu.cn
• Phone: 13395080173

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.