Magnesium sulfate to improve oxygenation and lung mechanics during one-lung ventilation
Official title: Effects of Magnesium Sulfate on Intraoperative Oxygenation and Lung Mechanics During One-Lung Ventilation: A Prospective Observational Study
Run by Marmara University · NCT07325773 · Data updated 2026-11-12
This project tests whether intravenous magnesium sulfate given during one-lung ventilation improves oxygen levels and lung mechanics in adults having elective VATS thoracic surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 104 (estimated) |
| Sponsor | Marmara University Academic / other |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | December 1, 2025 |
| Main results expected | July 15, 2026 |
| Study ends | November 28, 2026 |
| Registry record updated | January 8, 2026 |
| Trial ID | NCT07325773 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 scheduled for elective VATS with planned one-lung ventilation, ASA II–III, able to consent, and without severe renal, hepatic, or cardiac failure are the intended participants.
✕Probably not a fit
Patients undergoing pneumonectomy, those with major organ failure, very low preoperative FEV1 (<1.5 L), extreme BMI (<15 or >35 kg/m²), or those extubated to ICU while intubated postoperatively are unlikely to benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational comparison of patients who receive intravenous magnesium sulfate as part of routine anesthetic care versus those who do not during elective video-assisted thoracoscopic surgery requiring one-lung ventilation. Oxygenation metrics, dynamic and static lung mechanics, airway pressures, and ventilation-related indices will be recorded throughout the intraoperative period. Patients meeting inclusion criteria (age 18–80, ASA II–III, double-lumen tube placement) will be followed, while predefined exclusion criteria (e.g., pneumonectomy, significant organ failure, extreme BMI, very low preop FEV1) will omit ineligible cases. Data will be analyzed to determine whether intraoperative magnesium administration is associated with measurable differences in gas exchange or respiratory mechanics.
Why it matters
Potential benefit: If beneficial, intraoperative magnesium sulfate could improve oxygenation and make lung mechanics easier to manage during one-lung ventilation.
How similar studies have gone: Prior small studies and reports have suggested magnesium sulfate has bronchodilatory and anti-inflammatory effects, but evidence specifically showing benefit during one-lung ventilation is limited and not well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Adults aged 18 to 80 years Scheduled for elective thoracic surgery performed with video-assisted thoracoscopic surgery (VATS) requiring one-lung ventilation under general anesthesia. ASA physical status II-III Ability to provide informed consent Undergoing general anesthesia with double-lumen tube placement Exclusion Criteria: * Patients undergoing pneumonectomy * Patients with renal, hepatic, or cardiovascular failure * Patients with a BMI \< 15 kg/m² or \> 35 kg/m² * Patients with a preoperative pulmonary function test showing FEV₁ \< 1.5 liters * Patients who are transferred to the intensive care unit intubated in the postoperative period * Patients with physical or mental conditions that prevent the performance of pulmonary function testing factors
Where it's running
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Marmara University Faculty of Medicine, Basibuyuk Campus
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: İlayda AKARSU KAYA — Marmara University Faculty of Medicine, Department of Anesthesiology and Reanimation
- Study coordinator: İlayda AKARSU KAYA, Anesthesiology Resident, Principal Investigator
- Email: ilaydaakarsu96@gmail.com
- Phone: +905073306901
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.