Magnesium sulfate to improve oxygenation and lung mechanics during one-lung ventilation
Effects of Magnesium Sulfate on Intraoperative Oxygenation and Lung Mechanics During One-Lung Ventilation: A Prospective Observational Study
This project tests whether intravenous magnesium sulfate given during one-lung ventilation improves oxygen levels and lung mechanics in adults having elective VATS thoracic surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 104 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Marmara University Academic / other |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT07325773 on ClinicalTrials.gov |
What this trial studies
This is a prospective observational comparison of patients who receive intravenous magnesium sulfate as part of routine anesthetic care versus those who do not during elective video-assisted thoracoscopic surgery requiring one-lung ventilation. Oxygenation metrics, dynamic and static lung mechanics, airway pressures, and ventilation-related indices will be recorded throughout the intraoperative period. Patients meeting inclusion criteria (age 18–80, ASA II–III, double-lumen tube placement) will be followed, while predefined exclusion criteria (e.g., pneumonectomy, significant organ failure, extreme BMI, very low preop FEV1) will omit ineligible cases. Data will be analyzed to determine whether intraoperative magnesium administration is associated with measurable differences in gas exchange or respiratory mechanics.
Who should consider this trial
Good fit: Adults aged 18–80 scheduled for elective VATS with planned one-lung ventilation, ASA II–III, able to consent, and without severe renal, hepatic, or cardiac failure are the intended participants.
Not a fit: Patients undergoing pneumonectomy, those with major organ failure, very low preoperative FEV1 (<1.5 L), extreme BMI (<15 or >35 kg/m²), or those extubated to ICU while intubated postoperatively are unlikely to benefit from the findings.
Why it matters
Potential benefit: If beneficial, intraoperative magnesium sulfate could improve oxygenation and make lung mechanics easier to manage during one-lung ventilation.
How similar studies have performed: Prior small studies and reports have suggested magnesium sulfate has bronchodilatory and anti-inflammatory effects, but evidence specifically showing benefit during one-lung ventilation is limited and not well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Adults aged 18 to 80 years Scheduled for elective thoracic surgery performed with video-assisted thoracoscopic surgery (VATS) requiring one-lung ventilation under general anesthesia. ASA physical status II-III Ability to provide informed consent Undergoing general anesthesia with double-lumen tube placement Exclusion Criteria: * Patients undergoing pneumonectomy * Patients with renal, hepatic, or cardiovascular failure * Patients with a BMI \< 15 kg/m² or \> 35 kg/m² * Patients with a preoperative pulmonary function test showing FEV₁ \< 1.5 liters * Patients who are transferred to the intensive care unit intubated in the postoperative period * Patients with physical or mental conditions that prevent the performance of pulmonary function testing factors
Where this trial is running
Istanbul
- Marmara University Faculty of Medicine, Basibuyuk Campus — Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: İlayda AKARSU KAYA — Marmara University Faculty of Medicine, Department of Anesthesiology and Reanimation
- Study coordinator: İlayda AKARSU KAYA, Anesthesiology Resident, Principal Investigator
- Email: ilaydaakarsu96@gmail.com
- Phone: +905073306901
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.