Machine learning–assisted chemical profiling to rapidly ID bloodstream infection pathogens
Official title: Towards a Smart Blood Culture Bottle: Machine Learning Assisted Electrochemical Profiling to Provide Early In-situ Identification of Bloodstream Infections Pathogens
Run by University Hospital, Grenoble · NCT06853301 · Data updated 2026-11-12
This study tests a new method that uses machine learning and electrochemical signals from blood culture bottles to quickly identify the bacteria causing a bloodstream infection.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University Hospital, Grenoble Academic / other |
| Locations | 2 sites (Grenoble and 1 other locations) |
| Status | Recruiting |
| Started | July 13, 2026 |
| Main results expected | January 2028 |
| Study ends | January 2028 |
| Registry record updated | July 22, 2026 |
| Trial ID | NCT06853301 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥50 kg) needing standard blood culture collection and for whom 2–4 additional bottles can be collected without undue risk.
✕Probably not a fit
Patients on ongoing antibiotics at sampling or those in whom additional blood draws are not feasible may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The project aims to analyze electrochemical profiles of bacteria growing in blood culture bottles and apply machine learning to create a rapid identification database. It leverages the time between blood collection and culture bottle positivity to speed up actionable results. The approach combines innovative electrochemical sensing with AI to potentially shorten the time to targeted therapy. This is an interventional effort focused on improving early pathogen identification in bacteremia while patients receive standard care blood cultures.
Why it matters
Potential benefit: If successful, patients with bloodstream infections could receive targeted treatment sooner, potentially improving outcomes.
How similar studies have gone: Prior work shows promise for rapid pathogen identification using electrochemical signals and AI, but this exact approach is exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patient requiring a blood culture sample as standard of care procedure * body weight \> 50 Kg * Patient for whom the collection of 2 to 4 additional blood culture bottles is feasible, depending on venous access * patient who has not objected to participation in the project Exclusion Criteria: * Patient protected under the French Public Health Code (pregnant or breastfeeding women, patients under guardianship or curatorship, hospitalized under constraint, or deprived of liberty) * patients with ongoing antibiotic treatment at the time of sampling
Where it's running
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Grenoble University Hospital
Grenoble, France Recruiting -
Hôpital AVICENNE (AP-HP)
Paris, France Not yet recruiting
Study contacts
- Study coordinator: Yvan CASPAR, PharmD, PhD
- Email: YCaspar@chu-grenoble.fr
- Phone: +33 476765479
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Oral switch for bloodstream infections in immunocompromised children
This trial tests whether switching from IV to oral antibiotics is just as safe as continuing IV therapy for children with bloodstream infections who are immunocompromised or have a central venous catheter.
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Oral switch for kids with bloodstream infections after starting IV therapy
This trial will test whether switching from IV to oral antibiotics early is not worse than continuing IV treatment for previously healthy children and teens with uncomplicated bloodstream infections.
-
Fast antibiotic sensitivity tests to guide treatment for bloodstream infections
This tests whether rapid antibiotic susceptibility tests can help doctors pick the right antibiotics sooner for adults with positive blood cultures and improve recovery and antibiotic use.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.