Lung Health Check Pilot

The Lung Health Check Pilot

This pilot tries to see if offering a lung health check—including lung function tests and a low-dose CT scan—can find lung cancer early in people aged 55–74 who currently smoke or used to smoke in Ireland.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 2183 (estimated)
• Ages: 55 Years to 74 Years
• Sex: All
• Sponsor: Royal College of Surgeons, Ireland (Academic / other)
• Drugs / interventions: radiation
• Locations: 1 site (Dublin)
• Trial ID: NCT07099027 on ClinicalTrials.gov

What this trial studies

The pilot invites people aged 55–74 who are current or former smokers and referred by their GP to undergo a lung health check consisting of lung function tests and a low-dose CT scan. Participants are selected using established lung cancer risk scores (PLCOM2012 ≥ 1.51% or LLPv2 ≥ 2.5%) and are excluded if they had a chest CT in the last 12 months or have recent advanced cancers, recent lung cancer, or cannot undergo non-contrast CT. The programme is delivered at Beaumont RCSI Cancer Centre and focuses on detecting lung cancer before symptoms develop so disease can be treated earlier. This is a feasibility pilot to see if this screening pathway can be implemented in Ireland and to refine processes for larger rollout.

Who should consider this trial

Good fit: Ideal candidates are people aged 55–74 who currently smoke or formerly smoked, have a sufficient calculated lung-cancer risk (PLCOM2012 ≥1.51% or LLPv2 ≥2.5%), and are referred by their GP.

Not a fit: People outside the 55–74 age range, never-smokers, those who had a chest CT in the past 12 months, residents of nursing homes, or those unable to undergo or attend CT visits are unlikely to benefit from this pilot.

Why it matters

Potential benefit: If successful, the programme could detect lung cancer at an earlier, more treatable stage and thereby reduce deaths from the disease.

How similar studies have performed: Large trials such as the NLST and major European studies have shown low-dose CT screening can reduce lung cancer mortality by about 20–26%, so this approach has proven effectiveness elsewhere.

Eligibility criteria

Inclusion Criteria:

1. 55 - 74 years of age
2. Current or former smokers

   * Current: \>100 cigarettes in lifetime and/or currently tobacco smoking
   * Former: \>100 cigarettes in lifetime and/or no tobacco smoking \>= 28 days
3. Referred from a GP for the LHC pilot
4. PLCOM2012 ≥ 1.51% or LLPv2 ≥2.5% (Lung Cancer Risk Scores)

   * Prostate Lung Cancer Colorectal Ovarian (PLCO) \& Liverpool Lung Project Version 2 (LLPv2)

Exclusion Criteria:

1. Participant-reported history of chest CT in the last 12 months
2. Inability to undergo non-contrast CT (e.g. \>200 kg body weight, inability to lie flat)
3. Participant reported known diagnosis of other advanced stage cancers
4. Participant reported diagnosis of lung cancer of any stage in the last 5 years
5. Likely non-compliance with study procedures, as determined by the participant i) Unable to provide informed consent ii) Inability to attend study visits
6. Nursing home residents -

Where this trial is running

Dublin

• Beaumont RCSI Cancer Centre — Dublin, Ireland (Recruiting)

Study contacts

• Principal investigator: Jarushka Naidoo, MD — Beaumont RCSI Cancer Centre
• Study coordinator: Sandra Roche, PhD

Conditions Non-Small Cell Lung Cancer; Screening; Lung cancer