Lung compliance–guided ventilation during lumbar spine fixation
Impact of Dynamic Compliance-guided Ventilation on Postoperative Pulmonary Function in Lumbar Stabilization Surgery:A Prospective Study
This trial will try adjusting the ventilator in real time to each patient's lung compliance during lumbar stabilization surgery to see if it improves breathing and reduces lung complications after the operation compared with standard ventilation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 71 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Ankara City Hospital Bilkent Academic / other |
| Locations | 1 site (Ankara) |
| Trial ID | NCT07349719 on ClinicalTrials.gov |
What this trial studies
This is a prospective, randomized study that assigns patients undergoing lumbar stabilization in the prone position to either dynamic compliance–guided ventilation or standard ventilation. The compliance-guided approach continuously adjusts ventilator settings based on real-time lung compliance, while the control arm uses conventional fixed ventilation settings. The main outcomes focus on postoperative pulmonary function and the rate of postoperative pulmonary complications. Key exclusions include very high ASA class, extreme BMI, prior lung surgery, severe chronic lung disease, recent myocardial infarction, neuromuscular disease, and contraindications to PEEP.
Who should consider this trial
Good fit: Adults scheduled for lumbar stabilization in the prone position who meet ASA I–III, have a BMI between 18 and 30, and do not have severe heart or lung disease are the intended candidates.
Not a fit: Patients with severe COPD or asthma, recent myocardial infarction, ASA class IV or higher, extreme BMI, prior lung surgery, neuromuscular disease, or contraindications to PEEP are unlikely to benefit and are excluded from participation.
Why it matters
Potential benefit: If successful, this method could reduce postoperative pulmonary complications and improve early lung function after lumbar stabilization surgery.
How similar studies have performed: Individualized, lung-protective ventilation strategies have shown benefit in some surgical and critical care settings, but dynamic compliance–guided ventilation in lumbar surgery is relatively novel with limited direct evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who will undergo lumbar stabilization in the prone position Exclusion Criteria: * Patients with ASA classification IV or higher * Patients with obesity (BMI\>30) or cachexia (BMI\<18) * Allergy to standard medications used during general anesthesia * Contraindications to PEEP (high intracranial pressure, bronchopleural fistula, hypovolemic shock, right heart failure) * Previous lung surgery (any) * Known serious heart disease defined as New York Heart Association class III or higher * Patients with severe asthma and COPD * Acute myocardial infarction within the last 12 months before surgery * Neuromuscular disease
Where this trial is running
Ankara
- Ankara Bilkent City Hospital — Ankara, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Burak Nalbant
- Email: buraknalbant@gmail.com
- Phone: +905300148686
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.