Lung cancer screening using low-dose CT scans in high-risk individuals
Lung Cancer Screening With Low-dose CT in China (CLUS Study) Version 3.0
This study is testing if low-dose CT scans can help find lung cancer earlier in people aged 45 to 75 who are at high risk.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100000 (estimated) |
| Ages | 45 Years to 75 Years |
| Sex | All |
| Sponsor | Shanghai Chest Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT05494021 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of various lung cancer screening strategies, specifically focusing on low-dose computed tomography (LDCT) in high-risk individuals aged 45-75. It aims to validate previous findings that showed a significant increase in early-stage lung cancer detection through LDCT compared to usual care. The study involves recruiting 100,000 participants who will undergo baseline and two biennial LDCT screenings, with follow-up assessments for lung cancer incidence and mortality. Additionally, blood samples will be collected for future research purposes.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 45-75 with a history of significant smoking, family history of cancer, or exposure to carcinogens.
Not a fit: Patients who have had a chest CT scan in the past 12 months or a history of any cancer within the last 5 years may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly improve early detection of lung cancer, leading to better patient outcomes and reduced mortality rates.
How similar studies have performed: Previous versions of this study have shown success in increasing early-stage lung cancer detection rates, indicating a promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Eligible participants were those aged 45-75 years, and with either of the following risk factors: 1. history of cigarette smoking ≥ 20 pack-years, and, if former smokers, had quit within the previous 15 years; 2. malignant tumors history in immediate family members; 3. personal cancer history; 4. professional exposure to carcinogens; 5. long term exposure to second-hand smoke; 6. long term exposure to cooking oil fumes. Exclusion Criteria: * Had a CT scan of chest within last 12 months * History of any cancer within 5 years
Where this trial is running
Shanghai, Shanghai Municipality
- Shanghai Chest hospital — Shanghai, Shanghai Municipality, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.