Lung cancer screening using low-dose CT and biomarkers in Singapore

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the feasibility of implementing low-dose CT (LDCT) screening for lung cancer in at-risk populations in Singapore, including both smokers and non-smokers. Participants aged 50-80 with a family history of lung cancer will undergo LDCT screening and biomarker testing to gather data on lung adenocarcinoma, particularly in never-smokers. The study will classify scan results using the Lung-RADS system to guide further management and follow-up for participants with concerning findings. The goal is to establish a systematic screening approach that addresses local epidemiological needs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Smoker:

* Participant is willing and able to give informed consent for participation in the study
* Male or female, aged 50-80 years of age
* No prior history of cancer, or cancer free in the last 5 years and not currently on cancer treatment
* ECOG 0/1
* Current or former smokers with at least 30 pack years of smoking history
* Willing to comply with study follow-up schedule and tests
* Willing to cover the costs of downstream standard of care management and investigations including doctor's fee, CT scan and biopsy etc.
* A Singapore citizen/Permanent Resident of Singapore

Non-Smoker:

* Participant is willing and able to give informed consent for participation in the study
* Male, or female, aged 50-80 years of age
* No prior history of cancer, or cancer free in the last 5 years and not currently on cancer treatment
* ECOG 0/1
* Never smoker, or has smoked less than 10 pack-years and has quit smoking for at least 15 years
* Family history of lung cancer up to 2nd degree relatives
* Willing to comply with study follow-up schedule and tests
* Willing to cover the costs of downstream standard of care management and investigations including doctor's fee, CT scan and biopsy etc.
* A Singapore citizen/Permanent Resident of Singapore

Exclusion Criteria:

* Uncontrolled medical comorbidity on enrolment
* Previous diagnosis of cancer
* Bleeding diathesis that will preclude blood sampling
* Fear of blood draw or needles
* Pregnancy

Where it's running

• National Cancer Centre, Singapore
  Singapore, Singapore Recruiting
• Singapore General Hospital
  Singapore, Singapore Recruiting
• Tan Tock Seng Hospital, Singapore
  Singapore, Singapore Recruiting
• Changi General Hospital, Singapore
  Singapore, Singapore Recruiting
• Sengkang General Hospital, Singapore
  Singapore, Singapore Recruiting
• National Heart Centre Singapore
  Singapore, Singapore Active not recruiting

Study contacts

• Principal investigator: Darren Wan-Teck Lim, MD — National Cancer Centre, Singapore
• Study coordinator: Darren Wan-Teck Lim, MD
• Email: darren.lim.w.t@singhealth.com.sg
• Phone: 64368000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.