Lung cancer screening using low-dose CT and biomarkers in Singapore
SingapOre Lung Cancer Screening Through Integrating CT With Other biomarkErs (SOLSTICE)
This study is testing if low-dose CT scans and biomarker tests can help find lung cancer early in people aged 50-80 in Singapore who are at risk, including both smokers and non-smokers.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1000 (estimated) |
| Ages | 50 Years to 80 Years |
| Sex | All |
| Sponsor | National Cancer Centre, Singapore Academic / other |
| Locations | 3 sites (Singapore and 2 other locations) |
| Trial ID | NCT05724264 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the feasibility of implementing low-dose CT (LDCT) screening for lung cancer in at-risk populations in Singapore, including both smokers and non-smokers. Participants aged 50-80 with a family history of lung cancer will undergo LDCT screening and biomarker testing to gather data on lung adenocarcinoma, particularly in never-smokers. The study will classify scan results using the Lung-RADS system to guide further management and follow-up for participants with concerning findings. The goal is to establish a systematic screening approach that addresses local epidemiological needs.
Who should consider this trial
Good fit: Ideal candidates include smokers and non-smokers aged 50-80 with a family history of lung cancer.
Not a fit: Patients with a prior history of cancer or currently undergoing cancer treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and management of lung cancer in at-risk populations in Singapore.
How similar studies have performed: Other studies have shown success with similar LDCT screening approaches, particularly in high-risk populations, but this specific focus on the Singaporean context is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Smoker: * Participant is willing and able to give informed consent for participation in the study * Male or female, aged 50-80 years of age * No prior history of cancer, or cancer free in the last 5 years and not currently on cancer treatment * ECOG 0/1 * Current or former smokers with at least 30 pack years of smoking history * Willing to comply with study follow-up schedule and tests * Willing to cover the costs of downstream standard of care management and investigations including doctor's fee, CT scan and biopsy etc. * A Singapore citizen/Permanent Resident of Singapore Non-Smoker: * Participant is willing and able to give informed consent for participation in the study * Male, or female, aged 50-80 years of age * No prior history of cancer, or cancer free in the last 5 years and not currently on cancer treatment * ECOG 0/1 * Never smoker, or has smoked less than 10 pack-years and has quit smoking for at least 15 years * Family history of lung cancer up to 2nd degree relatives * Willing to comply with study follow-up schedule and tests * Willing to cover the costs of downstream standard of care management and investigations including doctor's fee, CT scan and biopsy etc. * A Singapore citizen/Permanent Resident of Singapore Exclusion Criteria: * Uncontrolled medical comorbidity on enrolment * Previous diagnosis of cancer * Bleeding diathesis that will preclude blood sampling * Fear of blood draw or needles * Pregnancy
Where this trial is running
Singapore and 2 other locations
- National Cancer Centre, Singapore — Singapore, Singapore (Recruiting)
- Singapore General Hospital — Singapore, Singapore (Recruiting)
- National Heart Centre Singapore — Singapore, Singapore (Recruiting)
Study contacts
- Principal investigator: Darren Wan-Teck Lim, MD — National Cancer Centre, Singapore
- Study coordinator: Darren Wan-Teck Lim, MD
- Email: darren.lim.w.t@singhealth.com.sg
- Phone: 64368000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.