Lung cancer screening for high-risk Black women
Evaluating the Feasibility of Lung Cancer Screening in High-risk Black Individuals
This study is testing if low-dose CT scans for lung cancer are acceptable and helpful for high-risk Black women who have a history of smoking.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 900 (estimated) |
| Ages | 50 Years to 80 Years |
| Sex | All |
| Sponsor | Massachusetts General Hospital Academic / other |
| Locations | 2 sites (Chicago, Illinois and 1 other locations) |
| Trial ID | NCT05898594 on ClinicalTrials.gov |
What this trial studies
This pilot research evaluates the feasibility and acceptability of low-dose computed tomography (LDCT) screening for lung cancer specifically among U.S. Black women with a history of smoking. The study involves screening participants for eligibility, administering questionnaires, and conducting LDCT scans. It aims to address the current gap in lung cancer screening eligibility for high-risk Black women, who are often overlooked in existing guidelines. Participation is expected to last up to three months, with around 900 participants involved.
Who should consider this trial
Good fit: Ideal candidates are self-identified Black women aged 50 and older with a history of smoking.
Not a fit: Patients with a history of lung cancer or current symptoms suggestive of lung cancer will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve early detection of lung cancer in high-risk Black women, potentially leading to better outcomes.
How similar studies have performed: While LDCT screening has been successful in other populations, this specific focus on high-risk Black women is novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Self-identified Black individual. * Have a self-reported history of smoking. No restriction will be placed on the number of smoking pack years participants must have nor the number of years former smokers must have quit smoking. * Aged 50-80 years. Exclusion Criteria: * Individuals with a history of lung cancer. * Individuals with symptoms suggestive of lung cancer. We will evaluate whether individuals have symptoms suggestive of lung cancer by administering an online screening questionnaire, which will ask whether they have experienced shortness of breath, whether they become easily winded, and whether they have had a chronic cough within the last 12 weeks that has not improved. Individuals who select that they have any one of these symptoms will be advised to follow up with their primary doctor and will not be eligible to participate in the study. * Individuals with pneumonia or acute respiratory infection within 12 weeks prior to enrollment that was treated with antibiotics.
Where this trial is running
Chicago, Illinois and 1 other locations
- University of Chicago — Chicago, Illinois, United States (Recruiting)
- Massachusetts General Hospital Cancer Center — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Chi Fu Jeffrey Yang, MD — Massachusetts General Hospital
- Study coordinator: Chi Fu Jeffrey Yang, MD
- Email: cjyang@mgh.harvard.edu
- Phone: 617-724-1681
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.