Lumbar erector spinae plane block to reduce pain after total hip replacement
Official title: Ultrasound-Guided Lumbal Erector Spinae Plane Block on Postoperative Pain Management After Total Hip Arthroplasty
Run by University Tunis El Manar · NCT07240961 · Data updated 2026-11-12
This trial will test whether a lumbar erector spinae plane block given after anesthesia lowers opioid use and pain for adults having a primary total hip replacement.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | University Tunis El Manar Academic / other |
| Locations | 1 site (Manouba) |
| Status | Recruiting |
| Started | November 1, 2025 |
| Main results expected | June 30, 2026 |
| Study ends | July 7, 2026 |
| Registry record updated | November 21, 2025 |
| Trial ID | NCT07240961 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 years old, ASA I-III, scheduled for a primary unilateral total hip arthroplasty via a lateral approach under general anesthesia and meeting the study's weight and renal function criteria are ideal candidates.
✕Probably not a fit
Patients with contraindications to regional anesthesia or NSAIDs, allergies to opioids or paracetamol, creatinine clearance below 30 mL/min, weight under 50 kg or over 100 kg, psychiatric or communication difficulties, lower limb neurological deficits, or those having bilateral or revision hip replacement are unlikely to be eligible or to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, randomized trial comparing an ultrasound-guided lumbar erector spinae plane block (ESPB) plus standard multimodal analgesia versus standard multimodal analgesia alone in adults undergoing primary total hip arthroplasty under general anesthesia. After induction, participants randomized to the ESPB group receive a single-shot lumbar ESP block (30 mL of 0.25% bupivacaine or 0.2% ropivacaine) placed at the L4 transverse process under ultrasound guidance, while the control group receives no block. All patients receive the same postoperative regimen including IV then oral paracetamol, oral diclofenac, and PCA morphine for rescue; patients are observed in a continuous care unit for 24 hours. The primary outcome is opioid consumption in the first 24 postoperative hours, with secondary outcomes including measures of pain and recovery.
Why it matters
Potential benefit: If successful, the block could reduce opioid use and improve postoperative pain control after hip replacement, potentially lowering opioid-related side effects.
How similar studies have gone: Small case series and some reports in the literature suggest lumbar ESPB can provide effective analgesia after hip surgery, but randomized data remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * primary total hip arthroplasty with lateral approach and under general anesthesia . Exclusion Criteria: * • Contraindication or refusal to regional anesthesia * Contraindication to non-steroidal anti-inflammatory (NSAID's) * Allergy to opioids * Allergy to paracetamol * Creatinine clearance \< 30ml/min * Weight\<50 kg or \>100kg * Psychiatric disorders and difficulty of communication * Lower limb neurological deficit * Patients undergoing bilateral or revision total hip replacement
Where it's running
-
Kassab Orthopedic Institute
Manouba, Tunisia Recruiting
Study contacts
- Study coordinator: Kaabachi Olfa
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.