Lowering home blood pressure targets for elderly patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates whether setting a lower target for home blood pressure (125/75 mmHg) compared to a standard target (135/85 mmHg) can reduce cardiovascular events in elderly patients with hypertension. It involves intensive home blood pressure control and aims to standardize home monitoring practices in community settings. Participants will be elderly individuals aged 60-80 who have been on antihypertensive medication for at least two weeks and have elevated home blood pressure readings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 60-80 years old
* Have been taking antihypertensive drugs for more than 2 weeks
* The average SBP and/or DBP of 7-day home blood pressure monitoring ≥135/85 mmHg
* Willing to participate, adhere to follow-up, and sign the written informed consent form

Exclusion Criteria:

* Arm circumference too large or too small (less than 18 cm or greater than 42 cm) to fit the cuff in case of inaccurate measurement
* Invalid home blood pressure monitoring. The valid home blood pressure monitoring requires consecutive measurements for at least 3 days, with not less than 1 measurement in the morning and evening, respectively.
* Office blood pressure indicates stage 3 clinic hypertension (≥180/110 mmHg) during the screening period
* Suspected or known secondary hypertension
* Orthostatic hypotension, defined as a decrease in systolic blood pressure greater than 20 mmHg or diastolic blood pressure greater than 10 mmHg within 3 minutes when position is changed from sitting to standing
* eGFR\<30 ml/min/1.73m2 or end-stage renal disease
* Cardiovascular events occured within the past 3 months, such as myocardial infarction, stroke, acute heart failure, hospitalization for unstable angina, undergoing coronary artery revascularization or bypass grafting
* Abnormal liver function (ALT/AST/total bilirubin more than 2 times the upper limit of normal value)
* Severe somatic disease with a life expectancy of less than 3 years, or diagnosed with cancer within the past 2 years requiring treatment
* Doctors deem that the participation would do harm to the patients or the patients would have poor compliance.

Where it's running

• Community hospitals
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Principal investigator: Yan Li, Professor — Shanghai Institute of Hypertension
• Study coordinator: Yan Li, Professor
• Email: liyanshcn@163.com
• Phone: +8613482234463

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.