Lowering high LDL-C with personality-tailored text messages
Official title: Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages: A Three-Arm Randomized Controlled Trial
Run by National University Health System, Singapore · NCT07415109 · Data updated 2026-11-12
This test checks whether a single personality-tailored text message helps adults with high LDL cholesterol make and attend GP appointments more often than a general message or no message.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years to 65 Years |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | National University Health System, Singapore Academic / other |
| Locations | 1 site (Singapore) |
| Status | Recruiting |
| Started | November 25, 2025 |
| Main results expected | January 2028 |
| Study ends | November 2028 |
| Registry record updated | April 13, 2026 |
| Trial ID | NCT07415109 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (21+) enrolled in RESET who were flagged with high LDL-C, consented to be contacted for future studies, and can read and write English.
✕Probably not a fit
People without elevated LDL-C, those unable to read or write English, or those already reliably attending GP follow-ups are unlikely to gain additional benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional program runs alongside the RESET study and enrolls RESET participants identified with high LDL-C who consented to recontact and can read English. Participants are randomized to receive either a one-time personality-tailored text message, a one-time general text message, or no message as a control, and they complete one questionnaire before and one after receiving their RESET results. The main outcome is whether participants arrange or attend a GP consultation after learning their LDL-C result. Messages are designed using temporal self-regulation theory and personalized by participant personality type to encourage prompt follow-up.
Why it matters
Potential benefit: If successful, this approach could increase GP follow-up for people with high LDL-C, enabling earlier treatment and better cholesterol control.
How similar studies have gone: Previous research shows personality-tailored and theory-based messages can improve some health behaviors, but evidence for one-time text messages improving clinic follow-up is mixed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * New participants of RESET who have given consent to be contacted for future studies * ≥21 years old Exclusion Criteria: * are not able to read, write or communicate in English
Where it's running
-
National University of Singapore
Singapore, Singapore Recruiting
Study contacts
- Study coordinator: Jocelyn Chew
- Email: dbi-lab@nus.edu.sg
- Phone: +6565168687
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.